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Richard H. Mattson, M.D.

Department of Neurology
Yale Univ. School of Medicine
15 York St.
PO Box 208018
West Haven, CT 06516

Email: richard.mattson@yale.edu

Education
The Taft School, Watertown, Connecticut 1949
Yale University, New Haven, Connecticut, B.S. 1953
Boston University, Boston, Massachusetts, M.D. 1957
University of Minnesota, Minneapolis, M.S. 1962
Yale University, New Haven, Connecticut M.A. (Hon) 1967

Internship - Wilford Hall Air Force Hospital 1957 - 1958

Residency - Neurology, Mayo Foundation 1958 - 1962
Neurophysiology, Mayo Foundation 1961 - 1962

Sabbatical - NINDS Epilepsy Branch 1988
Basic Mechanisms of Antiepileptic Drugs

Military - Active Duty, Major, U.S. Air Force (USAF) 1957 - 1967
Chief, Neurology Service, Wilford Hall USAF Hospital
Flight Medical Officer
Consultant in Neurology to the USAF Surgeon General
Neurology Advisor to Manned Orbital Lab

Academic Appointments

Clinical Assistant Professor, Neurology, 1966 - 1967
University of Texas, Medical Branch, Galveston
Assistant Professor, Neurology, Yale University School of Medicine (YMS) 1967 - 1971
Associate Clinical Professor, Neurology, YMS 1971 - 1977
Clinical Professor of Neurology, YMS 1977 - 1983
Professor of Neurology, YMS 1983 -
Director of Medical Studies (Education), Department of Neurology, YMS 1985 -
Vice Chairman for Academic Affairs, Department of Neurology, YMS 1996 - 1999

Board Certification

National Board of Medical Examiners 1960
American Board of Psychiatry and Neurology (N) 1964
American Board of Clinical Neurophysiology 1966

Honors

Begg Honor Society, Boston University 1955
HV Jones Medical Science Award, Mayo Foundation 1962
Outstanding Clinical Trial: International League Against Epilepsy (ILAE) 1986
Ambassador Award, ILAE 1989
Best Doctors in the USA 1992-
Silver "Cindy" Award, Epilepsy Foundation of America (EFA) 1993
Neurology Attending of the Year, YMS 1993
William J. Lennox Award, American Epilepsy Society (AES) 1994
Who's Who in America, Healthcare, Science, World 1996 Hans Berger Lecturer 1997
Novartis ILAE/IBE Epileptology Prize 1997
AES/MILLKEN Clinical Investigator Award 1997
Hans Berger Distinguished Scholar Award 2001

Hospital Appointments

Chief, Neurology Service, Wilford Hall USAF Hospital 1963 - 1967
Consultant in Neurology, Connecticut Mental Health Center 1967 - 1969
Assistant Chief, Neurology Service, Veterans Administration
Medical Center (VAMC) 1967 - 1978
Attending in Neurology, Hospital of St. Raphael 1967 - 1983
Attending in Neurology, Yale-New Haven Hospital 1967 -
Director, Epilepsy Center, Yale - VAMC 1971 - 1988
Chief, Seizure Clinic, Yale-New Haven Hospital 1973 - 1978
Chief, Neurology Service, VAMC, West Haven 1978 - 1993

Other Yale Appointments

Director, Neurology Residency Program, YMS 1985 - 1996
Director, Yale/NIH Program Project Grant 1985 -
Clinical Curriculum Committee, YMS 1985 -
Director, Neuroscience Clerkship, YMS III-IV 1989 -
Director, Neuroscience & Psychiatry Course, YMS II 1991 - 1998
Admissions Committee, YMS 1992 -1999
Secretary, Yale Neurology Alumni Association 1994 -

Society Memberships:

New Haven County Medical Association
Connecticut Neurological Society
American Medical Association
The American Academy of Neurology (AAN Fellow)
The American Neurologic Association (ANA)
The American Clinical Neurophysiology Society (ACNS)
The American Epilepsy Society (AES), Past President
Southern Clinical Neurological Society, President
The American Association for Advancement of Science
The Association for Research in Nervous and Mental Diseases

Other Appointments:

Chairman, International League Against Epilepsy,
Commission on Therapeutic Strategies 1997-
Examiner, American Board of Neurology and Psychiatry 1967 -
Examiner, American Board of Qualifications in Clinical Neurophysiology 1967-
Committee on the Classification of Epilepsy, ILAE 1976 -1993
Chairman, VA Multi-Center Cooperative Study "Efficacy of Antiepileptic 1976-
Drugs in the Treatment of Specific Seizure Types"
Epilepsy Foundation of America (EFA) Professional Advisory Board 1977 1996
National Liaison Member for the VA Hospitals 1977 -1996
Advisor to NINDS 1998-

Past Special Appointments (Selected):

Chairman, Program Committee, American Association 1973
of Electromyography and Electrodiagnosis
Program Committee, AAN 1974 and 1975
Chairman, VAMC Workshops on Epilepsy 1974 and 1976
Chairman, Special Committee which developed guidelines, 1975
"Standards of Clinical Electroencephalographers", ACNS
Vice Chairman, Connecticut Governor's Commission on Epilepsy 1976
Chairman, Research and Development Committee, VAMC 1977 and 1978
Epilepsy Advisory Council, National Institutes of Health 1977 - 1981
Secretary/Treasurer, Connecticut Neurological Society 1977 - 1987
Chairman, Program Committee, AES 1978
Committee on Flight Standards, Federal Aviation Administration 1979
Pharmacy Committee, VA Cooperative Studies Central Research 1979 - 1981
Program Committee, Epilepsy International 1979 and 1983Chairman, International Symposium on Epilepsy, Hormones and Pregnancy 1982 - 1983
Council, AES 1983 - 1987
Search Committee, YMS Chairman of Surgery 1984 - 1985
President, AES 1985 - 1986
Dean's Committee, VAMC 1985 - 1992
Cabinet Member, Yale New Haven Hospital 1986 - 1987
Director, Annual Course on Epilepsy AAN 1986 - 1989
Vice President, National Association of Epilepsy Centers 1987 - 1988
Representative for Northeast to Central Office Field 1989 - 1992
Advisory Group in Neurology (VA)

Editorial Boards

Clinical Therapeutics
CNS Drug Reviews
Seizure
Ad Hoc Reviewer: Lancet, JAMA, New England Journal of Medicine, Annals of Neurology, Archives of Neurology, Neurology, Epilepsia, Drugs.


ReferRed Publications

Bennett DR, Mattson RH, Ziter FA, Calverley JR, Liske EA, Pratt KL. Sleep deprivation: Neurologic and EEG effects. Aerospace Med 35:888-890, 1964.

Mattson RH. A good night's sleep. J Amer Med Assoc 194:292, 1965.

Mattson RH, Pratt KD, Calverley JR. Electroencephalograms of epileptics following sleep deprivation. Arch Neurol 13:310-315, 1965.

Mattson RH, Peterson EW. Glioblastoma multiform of the optic nerve. JA A 196:799-800, 1966.

Smith CK, Mattson RH. Seizures in Wilson's Disease. Neurology 17:1121-1123, 1967.

Mattson RH, Calverley JR. Dextroamphetamine-sulfate induced dyskinesias. J Amer Med Assoc 204:400-401, 1968.

Mattson RH, Lecocq R. Nerve conduction velocities in fasting patients. Neurology 18:335-339, 1968.

Pratt KL, Mattson RH, Weikers NJ, Williams R. EEG activation of epileptics following sleep deprivation: A prospective analysis of 114 cases. EEG Clin Neurophysiol 24:11-15, 1968.

Mattson RH, Weisman GK, Levy LL. Dependence and CNS toxicity associated with the use of propoxyphene hydrochloride. Trans Amer Neurol Assoc 94:299-301, 1969.

Weikers NJ, Mattson RH. Acute paralytic brachial neuritis. Neurology 19:1153-1158, 1969.

Gallagher BB, Smith DB, Mattson RH. The relationship of the anticonvulsant properties of primidone to phenobarbital. Epilepsia 11:293-301, 1970.

Baumel IP, Gallagher BB, Mattson RH. Phenylethylmalonamide (PEMA) - An important metabolite of primidone. Arch Neurol 27:34-41, 1972.

Gallagher BB, Baumel IP, Mattson RH. Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration. Neurology 22:1186-1192, 1972.

Reynolds EH, Gallagher BB, Mattson RH. Relationship between serum and cerebrospinal fluid folate. Nature 240:155-157, 1972.

Reynolds EH, Mattson RH, Gallagher BB. Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients. Neurology 22:841-844, 1972.

Wallace JD, Weintraub MIMattson RH, Rosnagle RJ. Status epilepticus as a complication of intrathecal fluorescein. J Neurosurg 36:659-660, 1972.

Gallagher BB, Baumel IP, Mattson RH, Woodbury SG. Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity. Neurology 23:145-149, 1973.

Mattson RH, Gallagher BB, Reynolds EH, Glass DH. Folate therapy in epilepsy: A controlled study. Arch Neurol 29:78-81, 1973.

Brillman J, Gallagher BB, Mattson RH. Acute primidone intoxication. Arch Neurol 30:255-258, 1974.

Glass DH, Mattson RH. Paroxysmal EEG activity during fixed ratio and DRL performance of temporal lobe epileptics. EEG Clin Neurophysio 37:204-220, 1974.

Mattson RH, Williamson PD, Hanahan E. Eterobarb therapy in epilepsy. Neurology 26:1014 1017, 1976.

Mattson RH, Cramer JA, Williamson PD, Novelly RA. Valproic acid in epilepsy: Clinical and pharmacological effects. Ann Neurol 3:20-25, 1978.

Cramer JA, Mattson RH. Valproic acid. In vitro plasma protein binding and interaction with phenytoin. Therap Drug Monit 1:105-116, 1979.

Daly DD, Bennett DR, Crandall PH, Mattson RH, Penry JK, Rasmussen TB. Seizure disorders and disturbances of consciousness - Panel 6. Arch Neurol 36:782-783, 1979.

Huttenlocher PR, Mattson RH. Isoprinosine in subacute sclerosing panencephalitis. Neurology 26:763-771, 1979.

Spencer SS, Williamson PD, Spencer DD, Mattson RH. Value of depth electroencephalography in 21 patients with refractory epilepsy. Trans Amer Neurol Assoc 104:241-243, 1979.

Delaney RC, Rosen AS, Mattson RH, Novelly RA. Memory function in focal epilepsy. A comparison of non-surgical unilateral temporal lobe and frontal lobe samples. Cortex 16:103-117, 1980.

Fay ML, Mattson RH. Clinical testing during intensive monitoring of ictal events. In: Advances in Epileptology. Tenth Epilepsy International Symposium, eds., JA Wada, JK Penry, Raven Press, New York, 65-68, 1980.

Mattson RH. Value of intensive monitoring. In: Advances in Epileptology. Tenth Epilepsy International Symposium, eds., JA Wada, JK Penry, Raven Press, New York, 43-52, 1980.

Mattson RH, Cramer JA. Valproic acid and ethosuximide interaction. Ann Neurol 7:583-584, 1980.

Soloway SS, Williamson PD, Spencer DD, Mattson RH. Surgery for epilepsy: Role of depth electroencephalography. Conn Med 44:70-75, 1980.

Williamson PD, Spencer DD, Spencer SS, Mattson RH. Presurgical intensive monitoring using depth electroencephalography in temporal lobe epilepsy. In: Advances in Epileptology. Tenth Epilepsy International Symposium, eds., JA Wada, JK Penry, Raven Press, New York, 73-84, 1980.

Delgado-Escueta AV, Mattson RH, King L, Goldensohn ES, Spiegel H, Madsen J, Crandall P, Dreifuss F, Porter R. Special report. The nature of aggression during epileptic seizures. N Eng J Med 305:711-716, 1981.

Spencer SS, Spencer DD, Williamson PD, Mattson RH. Ictal effects of anticonvulsant medication withdrawal in epileptic patients. Epilepsia 22:297-307, 1981.

Cramer JA, Mattson RH. A simple method to obtain unbound antiepileptic drugs in blood. Therap Drug Monit 4:107-108, 1982.

Mattson GF, Mattson RH, Cramer JA. Interaction between valproic acid and carbamazepine: An in vitro study of protein binding. Therap Drug Monit 4:181-184, 1982.

Spencer SS, Spencer DD, Williamson PD, Mattson RH. The localizing value of depth electroencephalography in 32 patients with refractory epilepsy. Ann Neurol 12:248-253, 1982.

Cramer JA, Bennett DM, Mattson RH. Free and bound valproic acid separated by two methods of ultrafiltration. Clin Chem 29:1441-1442, 1983.

Cramer JA, McCarthy KA, Mattson RH. Free fraction of valproic acid is the same in serum and plasma. Clin Chem 29:1449, 1983.

Cramer JA, Smith DB, Mattson RH, Delgado-Escueta AV, Collins JF, the VA Epilepsy Cooperative Study Group. A method of quantification for the evaluation of antiepileptic drug therapy. Neurology 33(Suppl 1):28-37, 1983.

Delgado-Escueta AV, Mattson RH, Smith DB, Cramer JA, Collins JF. Principles in designing clinical trials for antiepileptic drugs. Neurology 33(Suppl 1):8-14, 1983.

Mattson RH. Closed circuit televised videotape recording and electroencephalography (CCTV/EEG) in convulsive status epilepticus. In: Advances in Neurology. Symposium on Status Epilepticus, eds., AV Delgado-Escueta, CG Wasterlain, DM Treiman, RJ Porter, Raven Press, New York, 37-46, 1983.

Mattson RH, Cramer JA, Delgado-Escueta AV, Smith DB, Collins JF, the VA Epilepsy Cooperative Study Group. A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults. Neurology 33(Suppl 1):15-27, 1983.

Smith DB, Delgado-Escueta AV, Cramer JA, Mattson RH. Historical perspective on the choice of antiepileptic drugs for the treatment of seizures in adults. Neurology 33(Suppl 1):2-7, 1983.

Spencer SS, Spencer DD, Williamson PD, Mattson RH. Sexual automatisms in partial complex seizures. Neurol 33:527-533, 1983.

Spilker B, Wilder BJ, Bruni J, Mattson RH, Masland R, Resor S, Wannamaker B, Maddox R, Treiman DM, Geiger E, Peck M, Cloutier G. A multi-center study of the efficacy and safety of cinromide in patients with partial seizures. Curr Therap Res 34:7-14, 1983.

Swick CT, Williamson PD, Mattson RH, Spencer SS, Spencer DD. Depth electroencephalography. Am J EEG Tech 23 #1 March, 1983.

Augustine EA, Novelly RA, Mattson RH, Glaser GH, Williamson PD, Spencer DD, Spencer SS. Occupational adjustment following neurosurgical treatment of epilepsy. Ann Neurol 15:68-72, 1984.

Chatot CL, Klein NW, Clapper ML, Resor SR, Singer WD, Russman BS, Holmes GL, Mattson RH, Cramer JA. Human serum teratogenicity studied by rat embryo culture: Epilepsy, anticonvulsant drugs and nutrition. Epilepsia 25:205-216, 1984.

Mattson RH, Cramer JA, Caldwell BV, Siconolfi BC. Treatment of seizures with medroxyprogesterone acetate: A preliminary report. Neurology 34:1255-1258, 1984.

Mattson RH, Cramer JA, Siconolfi BC, Caldwell BV. Medroxy progesterone therapy for catamenial epilepsy. In: Advances in Epileptology: 15th Epilepsy International Symposium, ed., RJ Porter, Raven Press, New York, 279-282, 1984.

Novelly RA, Augustine EA, Mattson RH, Glaser GH, Williamson PD, Spencer DD, Spencer SS. Selective memory improvement and impairment in temporal lobectomy for epilepsy. Ann Neurol 15:64-67, 1984.

Sostman HD, Spencer DD, Gore JC, Spencer SS, Holcumb W, Williamson PD, Prichard JW, Camputaro C, Greenspan RH, Mattson RH. Preliminary observations on magnetic resonance imaging in refractory epilepsy. Magn Reson Imaging 2:301-306, 1984.

Spencer DD, Spencer SS, Mattson RH, Williamson PD. Intracerebral masses in patients with intractable partial epilepsy. Neurology 34:432-436, 1984.

Spencer DD, Spencer SS, Mattson RH, Williamson PD, Novelly RA. Access to the posterior medial temporal lobe structures in the surgical treatment of temporal lobe epilepsy. Neurosurgery 15:667-671, 1984.

Spencer SS, Spencer DD, Mattson RH, Williamson PD. More intense focal seizure types after callosal section. The role of inhibition. Ann Neurol 16:686-693, 1984.

Goodman RN, Williamson PD, Reeves AC, Spencer SS, Spencer DD, Mattson RH, Roberts DW. Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy. Neurology 35:1351-1354, 1985.

Mattson RH, Cramer JA. Epilepsy, sex hormones and antiepileptic drugs. Epilepsia 26(Suppl l ):S40-S51, 1985.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Eng J Med 313:145-151, 1985.

Spencer SS, Spencer DD, Williamson PD, Mattson RH. The effects of corpus callosum section on secondary bilaterally synchronous interictal electroencephalographic discharge. Neurology 35:1689-1694, 1985.

Spencer SS, Williamson PD, Bridgers SL, Mattson RH, Cicchetti DV, Spencer DD. Reliability and accuracy of localization by scalp ictal EEG. Neurology 35:1567-1575, 1985.

Williamson PD, Mattson RH, Spencer SS, Spencer DD. Complex partial status epilepticus: A depth electrode study. Ann Neurol 18: 647-654, 1985.

Williamson PD, Spencer DD, Spencer SS, Novelly RA, Mattson RH. Complex partial seizures of frontal lobe origin. Ann Neurol 18:497-504, 1985.

Williamson PD, Spencer DD, Spencer SS, Novelly RA, Mattson RH. Episodic aphemia and epileptic focus in non-dominant hemisphere: Relieved by section of corpus callosum. Neurology 35:1069-1071, 1985.

Cramer JA, Mattson RH, Bennett DM, Swick CT. Variable free and total valproic concentrations in sole and multi-drug therapy. Ther Drug Monit 8:411-415, 1986.

Delaney RC, Prevey ML, Mattson RH. Short-term retention with lateralized temporal lobe epilepsy. Cortex 22:591-600, 1986.

Eskenazi B, Cain WS, Novelly RA, Mattson RH. Odor perception in temporal lobe epilepsy patients with and without temporal lobectomy. Neuropsychologia 24:553-562, 1986.

Mattson RH. Intensive neurodiagnostic monitoring: Strategy for optimal use. In: Intensive Neurodiagnostic Monitoring, ed., R Gumnit, Raven Press, New York, 281-290, 1986.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Early tolerance to antiepileptic drug side-effects: A controlled trial of 247 patients. In: Tolerance to Beneficial and/or Adverse Effects of Antiepileptic Drugs, eds., HH Frey, et al., Raven Press, New York, 149-156, 1986.

Mattson RH, Cramer JA, Darney PD, Naftolin F. Use of oral contraceptives by women with epilepsy. J Amer Med Assoc 256:238-240, 1986.

Novelly RA, Schwartz MM, Mattson RH, Cramer JA. Behavioral toxicity associated with antiepileptic drugs: Concepts and methods of assessment. Epilepsia 24:331-340, 1986.

Smith DB, Craft BR, Collins JF, Mattson RH, Cramer JA, the VA Cooperative Study Group 118. Behavioral characteristics of epilepsy patients compared with normal controls. Epilepsia 27:760-768, 1986.

Browne TR, Mattson RH, Penry JK, et al. Vigabatrin for refractory complex partial seizures: Multicenter single-blind study with long-term follow up. Neurology 37:184-189,1987.

Cramer JA, Collins JF, Mattson RH. Can categorization of patient background problems be used to determine early termination in a clinical trial? Controlled Clin Trials 9:47-63, 1987.

Homan RW, Miller B, the VA Epilepsy Cooperative Study Group (Mattson RH). Causes of treatment failure with antiepileptic drugs vary over time. Neurology 37:1620-1623, 1987.

Smith DB, Mattson RH, Cramer JA, Collins JF, Novelly RA, Craft B, the VA Cooperative Study Group 224. Results of a nationwide Veterans Administration cooperative study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. Epilepsia 28:S50-S58, 1987.

Spencer SS, Williamson PD, Spencer DD and Mattson RH. Human hippocampal seizure spread studied by depth and subdural recording: The hippocampal commissure. Epilepsia 28:479-489, 1987.

Mattson RH, Cramer JA. Crossover from polytherapy to valproate monotherapy in primary generalized epilepsy. Am J Med 84(Suppl IA):S23-S28, 1988.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Aspects of compliance in epilepsy: Taking drugs and keeping clinic appointments. In: Compliance in Epilepsy (Epilepsy Research, Suppl 1), eds., I Leppik, D Schmidt, Elsevier, 111-117, 1988.

Prevey ML, Delaney RC, Mattson RH. Gist recall in temporal lobe seizure patients. Cortex 24:301-312, 1988.

Prevey ML, Delaney RC, Mattson RH. Metamemory in temporal lobe epilepsy. Self monitoring of memory functions. Brain Cogn 7:298-311, 1988.

Sass KJ, Spencer DD, Spencer SS, Novelly RA, Williamson PD, Mattson RH. Corpus callosotomy for epilepsy II: Neurological and neuropsychological outcome. Neurology 38:24-28, 1988.

Spencer SS, Spencer DD, Williamson PD, Sass KJ, Novelly RA, Mattson RH. Corpus callosotomy for epilepsy I: Seizure effects. Neurology 38:19-24, 1988.

Bronen R, Cheung G, Charles J, Spencer DD, Spencer SS, Baca S, Williamson PD, Mattson RH. Pathology study of mesial temporal sclerosis: Comparison of scalp, EEG, MR, CT, angiography. American Society of Neuroradiology, Orlando, March 19-24, 1989.

Browne TR, Mattson RH, Penry JK, et al. A multicenter study of vigabatrin for refractory complex partial seizures in the United States. Brit J Clin Pharmacol 27(Suppl 1):955-1005, 1989.

Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouellette VL. How often is medication taken as prescribed? A novel assessment technique. J Amer Med Assoc 261:3273-3277, 1989.

Delaney RC, Prevey ML, Mattson RH. Memory scanning and material-specificity with lateralized temporal lobe epilepsy. J Clin Exp Neuropsychol 11:48-49, 1989.

The Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome (Mattson RH). Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut syndrome. Epilepsia 30(Suppl 4):422-429, 1989.

Mattson RH, Cramer JA, McCuthen CB, the VA Epilepsy Cooperative Study Group. Barbiturate related connective tissue disorders. Arch Intern Med 149:911-914, 1989.

Mattson RH, Cramer JA, Scheyer RD, Hochholzer JM. Disinduction of valproate metabolism: Timing and magnitude of change. Proc Roy Soc Med Symposium Series 152:138-142, 1989.

Mattson RH, Prevey ML, Cramer JA, Novelly RA, Swick CT. Lifestyle changes in epilepsy patients following treatment with valproate. Proc Roy Soc Med Symposium Series 152:275-280, 1989.

Mikati MA, Browne TR, Collins JF, the VA Epilepsy Cooperative Study Group (Mattson RH). Time course of carbamazepine autoinduction. Neurology 39:592-594, 1989.

Prevey ML, Mattson RH, Cramer JA. Improvement in cognitive functioning and mood state after conversion to valproate monotherapy. Neurology 39:1640-1641, 1989.

Warrenburg S, Levine J, Schwartz GE, Fontana AF, Kerns RD, Delaney R, Mattson RH. Defensive coping and blood pressure reactivity in medical patients. J Behav Med 12:407-424, 1989.

Cramer JA, Scheyer RD, Mattson RH. Compliance declines between clinic visits. Arch Intern Med 150:1509-1510, 1990.

Mattson RH. Selection of drugs for the treatment of epilepsy. Semin Neurol 10:406-412, 1990.

Mattson RH, Fay ML, Sturman JK, Cramer JA, Wallace JD, Mattson EM. The effect of various patterns of alcohol use on seizures in patients with epilepsy. In: Alcohol and Seizures: Basic mechanisms and clinical concepts, eds., RJ Porter, RH Mattson, JA Cramer, I Diamond, FA Davis, Philadelphia, 233-240, 1990.

Nuwer MR, Browne TR, Dodson WE, Dreifuss FE, Engel J, Leppik IE, Mattson RH, Penry J, Treiman DW, Wilder BJ. Generic substitutions for antiepileptic drugs. Neurology 40:1647-1651, 1990.

Scheyer RD, Cramer JA, Toftness BR, Hochholzer JM, Mattson RH. In vivo determination of valproate binding constants during sole and multi-drug therapy. Ther Drug Monit 12:117-123, 1990.

Spencer SS, Spencer DD, Williamson PD, Mattson RH. Combined depth and subdural electrode investigation in uncontrolled epilepsy. Neurology 40:74-79, 1990.

Boon PA, Williamson PD, Fried I, Spencer DD, Novelly RA, Spencer SS, Mattson RH. Intracranial, intraaxial, space-occupying lesions in patients with intractable partial seizures: An anatomoclinical, neuropsychological, and surgical correlation. Epilepsia 32:467-476, 1991.

Browne TR, Mattson RH, Penry JK, Smith DB, Treiman DM, Wilder BJ, Ben-Menachen E, McBride RG, Sherry KM. Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: An update. Neurology 41:363-364, 1991.

Hirsch LJ, Spencer SS, Spencer DD, Williamson PD, Mattson RH. Temporal lobectomy in patients with bitemporal epilepsy defined by depth electroencephalography. Ann Neurol 30:347-356, 1991.

Hirsch LJ, Spencer SS, Williamson PD, Spencer DD, Mattson RH. Comparison of bitemporal and unitemporal epilepsy defined by depth electroencephalography. Ann Neurol 30:340-346, 1991.

Mattson RH. Emotional effects on seizure occurrence. In: Neurobehavioral Problems in Epilepsy, eds., D Smith, D Treiman, M Trimble, Raven Press, New York, 55:453-460, 1991.

Prevey ML, Delaney RC, De l'Aune W, Mattson RH. A method of assessing the efficacy of memory rehabilitation techniques using a "real world" memory task: Learning a computer language. J Rehab Res Development 4:28, 50-63, 1991.

Prevey ML, Delaney RC, Mattson RH, Tice DM. Feeling of knowing in temporal lobe epilepsy: Monitoring knowledge inaccessible to conscious recall. Cortex 27:81-92, 1991.

Spencer SS, Elequera ED, Williamson PD, Spencer DD, Mattson RH. Evolution of seizure characteristics after callosotomy. J Epilepsy 4:149-156, 1991.

Delaney RC, Prevey ML, Cramer JA, Mattson RH, the VA Epilepsy Cooperative Study Group 264. Test-retest comparability and control subject data for the Rey-Auditory Verbal Learning Test and Rey-Osterrieth/Taylor Complex Figures. Arch Clin Neuropsychol 7:523-528, 1992.

Johnson EW, de Lanerolle NC, Kim JC, Sundaresan S, Spencer DD, Mattson RH, Zoghbi SS, Baldwin RM, Hoffer PB, Seibyl JP, Innis RB. Central and peripheral benzodiazepine receptors. Neurology 42:811-815, 1992.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group 264. A comparison of valproate with carbamazepine for the treatment of partial seizures and secondarily generalized tonic-clonic seizures in adults. N Eng J Med 327:765-771, 1992.

Sutherling W, et al. (Mattson RH). Assessment: Magnetoencephalography. Neurology 42:1-4, 1992.

Williamson PD, Boon PA, Thadani VM, Darcey TM, Spencer DD, Spencer SS, Novelly RA, Mattson RH. Parietal lobe epilepsy: Diagnostic considerations and results of surgery. Ann Neurol 31:193-201, 1992.

Williamson PD, Thadani VM, Darcey TM, Spencer DD, Spencer SS, Mattson RH. Occipital lobe epilepsy: Clinical characteristics, seizure spread patterns, and results of surgery. Ann Neurol 31:3-13, 1992.

French JA, Williamson PD, Thadani VM, Darcy TM, Mattson RH, Spencer SS, Spencer DD. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol 34:774-780, 1993.

Mattson RH, Rebar RW. Contraceptive methods for women with neurologic disorders. Am J Obstet Gynecol, 168:2027-2032, 1993.

Rothman DL, Petroff OAC, Behar KL, Mattson RH. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci (Neurobiology) 90:1-5, 1993.

Scheyer RD, Hochholzer JM, Mattson RH. Near-patient rapid assay of phenytoin concentrations. Epilepsia 36: 1118-1125, 1993.

Spencer SS, Katz A, Ebersole JS, Novotny E, Mattson RH. Ictal EEG changes with corpus callosum section. Epilepsia 34:568-573, 1993.

Spencer SS, Spencer DD, Sass K, Westerveld M, Katz A, Mattson RH. Anterior, total, and two stage corpus callosum section: Differential and incremental seizure responses. Epilepsia 34:561 567, 1993.

The U.S. Gabapentin Study Group No.5, Mclean MJ, et al. (Mattson RH). Gabapentin as add on therapy in refractory partial epilepsy. Neurology 43:2292-2298, 1993.

Williamson PD, French JA, Thadani VM, Kim JH, Novelly RA, Spencer SS, Spencer DD, Mattson RH. Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology. Ann Neurol 34:781-787, 1993.

Mattson RH. Current challenges in the treatment of epilepsy. Neurology 44(Suppl 5):S4-S9, 1994.

Mattson RH, Petroff OAC, Rothman DL, Behar KL. Vigabatrin: Effects on human brain GABA levels by nuclear magnetic resonance spectroscopy. Epilepsia 53(Suppl 5):S29-S34, 1994.

Messenheimer J, et al. (Mattson RH). Lamotrigine therapy for partial seizures: A multicenter placebo-controlled, double-blind, cross-over trial. Epilepsia 35:113-121, 1994.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Effect on brain GABA of standard and high-dose vigabatrin in humans. Ann Neurol 36:296, 1994.

Saygi S, Spencer SS, Scheyer RD, Katz A, Mattson RH, Spencer DD. Differentiation of temporal lobe ictal behavior associated with hippocampal sclerosis and tumors of temporal lobe. Epilepsia 35:737-742, 1994.

Scheyer RD, Cramer JA, Mattson RH, the VA Cooperative Study Group 118. A pharmacodynamic approach to the estimate of carbamazepine autoinduction. J Pharm Sci 83:491 494, 1994.

Scheyer RD, During MJ, Cramer JA, Toftness BR, Hochholzer JM, Mattson RH. Simultaneous HPLC analysis of carbamazepine and carbamazepine epoxide in human brain microdialysate. J Liquid Chromatogr 17:1567, 1994.

Scheyer RD, During MJ, Hochholzer JM, Spencer DD, Cramer JA, Mattson RH. Phenytoin concentrations in the human brain: An in vivo microdialysis study. Epilepsy Research 18:227 232, 1994.

Scheyer RD, During MJ, Spencer DD, Cramer JA, Mattson RH. Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysis. Neurology 44:1469 1472, 1994.

The U.S. Gabapentin Study Group (Mattson RH). The long-term safety and efficacy of gabapentin (Neurontin) as add-on therapy in drug-resistant partial epilepsy. Epilepsy Research 18:67-73, 1994.

Mattson RH. Antiepileptic drug monitoring: A reappraisal. Epilepsia 36(Suppl 5):S22-S29, 1995.

Mattson RH. Comparing antiepileptic drugs. The Lancet 345:467-468, 1995.

Mattson RH. Efficacy and adverse effects of established and new antiepileptic drugs. Epilepsia 36(Suppl 2):S13-S26, 1995.

Mattson, RH. Update on pharmacotherapy for seizure disorders. Federal Practitioner(Suppl), 1995.

Mattson RH, Petroff OAC, Rothman D, Behar K. Vigabatrin: Effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurol Scand 162(Suppl):27-30, 1995.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Initial observations in the effect of vigabatrin on the in vivo 1H spectroscopic measurements of GABA, glutamate, and glutamine in human brain: The effect of vigabatrin. Epilepsia 36:457-464, 1995.

Scheyer RD, Hochholzer JM, Mattson RH. Near-patient rapid assay of carbamazepine concentrations. J Epilepsy, 8:99-103, 1995.

Kocsis JD, Mattson RH. GABA levels in the brain: A target for new antiepileptic drugs. The Neuroscientist 2(Suppl 6):326-334, 1996.

Mattson RH. Parenteral antiepileptic/anticonvulsant drugs. Neurology 46(Suppl 1):S8-S13, 1996.

Mattson RH. The Role of the Old and the New Antiepileptic Drugs in Special Populations: Mental and Multiple Handicaps. Epilepsia, 37(Suppl 6):s45-s53, 1996

Mattson RH, Cramer JA, Collins J, the VA Cooperative Epilepsy Study Group. Prognosis for total control of complex partial and secondary generalized tonic-clonic seizures. Neurology 47:68-76, 1996.

Petroff OAC, Rothman DL, Behar KL, Lamoureux D, Mattson RH. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol 39:95-99, 1996.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Human brain GABA levels rise rapidly after inititation of vigbatrin therapy. Neurology 47:1567-1571, 1996.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Human brain gamma-aminobutyric acid (GABA) levels and seizure control following initiation of vigabatrin therapy. Journal of Neurochemistry 47:1567-1571, 1996.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Human brain GABA levels rise following initiation of vigabatrin therapy , but fail to rise further with increasing dose. Neurology 46:1459 1463, 1996.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Low brain GABA is associated with poor seizure control. Ann Neurol 40:908-911, 1996.

Prevey ML, Delaney RC, Mattson RH, Cramer JA. Complex partial and secondarily generalized seizure patients: Cognitive functioning prior to treatment with antiepileptic medication. Epilepsy, (in press).

Prevey ML, Delaney RC, Cramer JA, Mattson RH, Collins JF, Cattanach L. The effect of valproate on cognitive functioning: A comparison with carbamazepine. Archives of Neurology 53:1008-1016, 1996.

Prevey ML, Delaney RC, Mattson RH, Cramer JA, Cattanach L. Behavioral toxicity battery for antiepileptic drug trials: Normative data for subjects 20-80 years of age. Epilepsia, 37(Suppl 5):173, 1996.

Rothman DL, Nehar KL, Mattson RH, Prichard JW, Novotny EJ, Petroff OAC. Homocanosine levels are elevated in epileptic patients taking vigabatrin: a novel measure of cortical pH. In: Proceedings of the International Society of Magnetic Resonance Medicine. Vol. 1, Society of Magnetic Resonance, Berkeley, California 1996, p130.

Prevey ML, Cattanach L, Delaney RC, Mattson RH. Behavioral toxicity battery: Comparison of performance by normal, young, middle aged and elderly adults. Journal of Neuropsychiatry and Clinical Neurosciences 9(Suppl 1): 166, 1997.

Petroff OAC, Rothman DL, Mattson RH. GAMA and homocarnosine measurements and seizure control: The clinical pharmacology of gabapentin. 1997

Prevey ML, Mattson RH, Delaney RC, Kim JH, Spencer SS, SpencerDD. Memory scanning in temporal lobe epilepsy: Relationship to hippocampal cell density. Journal of the International Neuropsychological Society, 3(Suppl 1):9, 1997.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Human occipital lobe homocarnosine increased after starting vigabatrin. Annals of Neurology 1997;42:473.

Petroff OAC, Behar KL, Rothman DL, Mattson RH. Vigabatrin increased human brain GABA and improved seizure control. Epilepsia 1997;38 (suppl 3): 171.

Mattson RH, Rothman DL, Behar KL, Petroff OAC. Gabapentin: a GABA active drug. Epilepsia 1997; 38 (suppl 3): 65-66.

Petroff OAC, Mattson RH, Behar KL, Hyder F, Rothman DL. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol 1998; 44:948-952.

Mattson RH. An overview of the new antiepileptic drugs. The Neurologist Sept 1998; 4 (suppl 5): S2-S10.

Mattson RH. Medical management of epilepsy in adults. Neurology 1998; 51 (suppl 4): S15 S20.

Petroff OAC, Hyder F, Collins TL, Mattson RH, Rothman DL. Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures. Epilepsia 1999 00.

Petroff OAC, Hyder F, Mattson, RH, Rothman DL. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology 1999; 52: 473-478.

Cramer JA, Fisher R, Ben-Menachem E, French J, Mattson RH. New antiepileptic drugs: Comparison of key clinical trials. Epilepsia 1999; 40 (5): 590-600.

Edited Books Or Supplements

Mattson RH. The design of clinical studies to assess the efficacy and toxicity of antiepileptic drugs. Neurology 33(Suppl 1), No 3, 1983.

Porter RJ, Mattson RH, Ward AA, Dam M., eds. Advances in Epileptology. 15th Epilepsy International Symposium. Raven Press, New York, 1984.

Porter RJ, Mattson RH, Cramer JA, Diamond I., eds. Alcohol and Seizures: Basic mechanisms and clinical concepts. FA Davis, Philadelphia, 1990.

Mattson RH. Managing epilepsy: The role of gabapentin. Neurology 44:Suppl 5, 1994.

Levy R, Mattson RH, Meldrum B., eds. Antiepileptic Drugs, Fourth Edition. Raven Press, New York, 1995.

Book Chapters And Reviews

Mattson RH. The benzodiazepines. In: Antiepileptic Drugs, eds., DM Woodbury, JK Penry, RP Schmidt, Raven Press, New York, 497-516, 1972.

Mattson RH. Valproate and the management of seizures. In: Current Neurology, Vol. 2, eds., HR Tyler, D Dawson, Houghton Miffin Publishing Co., Boston, 229-248, 1979.

Mattson RH. Eterobarb: Clinical aspects. In: Antiepileptic Drugs, Second Edition, eds., DM Woodbury, JK Penry, CE Pippenger, Raven Press, New York, 813-816, 1982.

Mattson RH. Valproate: Interactions with other drugs. In: Antiepileptic Drugs, Second Edition, eds., DM Woodbury, JK Penry, CE Pippenger, Raven Press, New York, 579-589, 1982.

Mattson RH, Cramer JA. Phenobarbital and toxicity. In: Antiepileptic Drugs, Second Edition, eds., DM Woodbury, JK Penry, CE Pippenger, Raven Press, New York, 351-363, 1982.

Mattson RH. Phenobarbital, primidone (mysoline) and mephobarbital (mebaral). In: Epilepsy: Diagnosis and management, eds., TR Browne, RG Feldman, Little, Brown and Co., Boston, 191 202, 1983.

Mattson RH. Seizures associated with alcohol use and alcohol withdrawal. In: Epilepsy: Diagnosis and management, eds., TR Browne, RG Feldman, Little, Brown and Co., Boston, 325 332, 1983.

Mattson RH, Cramer JA. Valproic acid. In: Epilepsy: Diagnosis and management, eds., TR Browne, RG Feldman, Little, Brown and Co., Boston, 225-234, 1983.

Mattson RH. Overview of the interrelationship among seizures, hormones and pregnancy. In: Advances in Epileptology. 15th Epilepsy International Symposium, eds., RJ Porter, RH Mattson, AA Ward, M Dam, Raven Press, New York, 197-199, 1984.

Mattson RH, Cramer JA. Assessment of antiepileptic drug efficacy and toxicity. In: Rational Approaches to Anticonvulsant Drug Therapy, eds., SD Shorvon, GB Birdwood, Hans Huber Publishers, Bern, 22-27, 1984.

Ebersole JS, Mattson RH, Williamson PD, Spencer SS, Glaser GH. Monitoring at the West Haven VA-Yale University School of Medicine Epilepsy Center. In: Long-term Monitoring in Epilepsy (EEG Suppl 37), eds., J Gotman, JR Ives, P Gloor, Elsevier Science Publishers B.V., Amsterdam, 357-369, 1985.



Prichard JW, Mattson RH. Barbiturates: An update. In: Recent Advances in Epilepsy, Vol. 3, eds., TA Pedley, BS Meldrum, Churchill Livingston, Edinburgh, 261-277, 1986.

Mattson RH. Selection of antiepileptic drug therapy. In: Antiepileptic Drugs, Third Edition, eds., RH Levy, FE Dreifuss, RH Mattson, B Meldrum, JK Penry, Raven Press, New York, 103 115, 1989.

Mattson RH, Cramer JA. Phenobarbital toxicity. In: Antiepileptic Drugs, Third Edition, eds., RH Levy, FE Dreifuss, RH Mattson, B Meldrum, JK Penry, Raven Press, New York, 341-356, 1989.

Mattson RH, Cramer JA. Valproate interactions with other antiepileptic drugs. In: Antiepileptic Drugs, Third Edition, eds., RH Levy, FE Dreifuss, RH Mattson, B Meldrum, JK Penry, Raven Press, New York, 621-632, 1989.

Cramer JA, Mattson RH. Fertility and hormonal changes. In: Comprehensive Epileptology, eds., M Dam, L Gram, Raven Press, New York, 289-298, 1990.

Mattson RH. Alcohol-related seizures. In: Alcohol and Seizures: Basic mechanisms and clinical concepts, eds., RJ Porter, RH Mattson, JA Cramer, I Diamond, FA Davis, Philadelphia, 143 147, 1990.

Mattson RH, Cramer JA. Primidone. In: Comprehensive Epileptology, eds., M Dam, L Gram, Raven Press, New York, 593-601, 1990.

Cramer JA, Mattson RH. Monitoring compliance with antiepileptic drug therapy. In: Patient Compliance in Medical Practice and Clinical Trials, eds., JA Cramer, B Spilker, Raven Press, New York, 123-138, 1991.

Mattson RH. Drug treatment of partial epilepsy. In: Frontal Lobe Seizures and Epilepsies, eds., P Chauvel, et al., Raven Press, New York, 43:643-650, 1992.

Mattson RH. Drug treatment of uncontrolled seizures. In: Surgical Treatment of Epilepsy (Epilepsy Research, Suppl 5), ed., WH Theodore, Elsevier Science Publishers, Amsterdam, 29 35, 1992.

Cramer JA, Mattson RH. Hormones and epilepsy. In: Treatment of Epilepsy: Principles and practice, ed., E Wyllie, Lea & Febiger, Philadelphia, 686-691, 1993.

Cramer JA, Mattson RH. Quantitative approaches to seizure severity. In: Quantitative Assessment of Epilepsy Care: Clinometric applications, eds., H Meinardi, JA Cramer, GA Baker, A Martins da Silva, Pergamon Press, New York, 55-72, 1993.

Mattson RH. Electroencephalographic (polygraphic) studies in the diagnosis of non-epileptic seizures. In: Non-epileptic Seizures, AJ Rowan, JR Gates, Butterworth-Heinemann, Boston, 85 93, 1993.

Mattson RH, Cramer JA. The choice of antiepileptic drugs in focal epilepsy. In: Treatment of Epilepsy: Principles and practice, ed., E Wyllie, Lea & Febiger, Philadelphia, 817-823, 1993.

Mattson RH, Cramer JA. Quantitative assessment of adverse drug effects. In: Quantitative Assessment of Epilepsy Care: Clinometric applications, eds., H Meinardi, JA Cramer, GA Baker, A Martins da Silva, Pergamon Press, New York, 123-135, 1993.

Cramer JA, Mattson RH. Compliance with antiepileptic drug therapy. In: Antiepileptic Drugs, Fourth Edition, eds., R Levy, RH Mattson, B Meldrum, Raven Press, New York, 149-159, 1995.

Cramer JA, Mattson RH. Phenobarbital toxicity. In: Antiepileptic Drugs, Fourth Edition, eds., R Levy, RH Mattson, B Meldrum, Raven Press, New York, 409-420, 1995.

Mattson RH. Selection of antiepileptic drug therapy. In: Antiepileptic Drugs, Fourth Edition, eds., R Levy, RH Mattson, B Meldrum, Raven Press, New York, 123-135, 1995.

Scheyer RD, Mattson RH. Valproate: Interactions with other drugs. In: Antiepileptic Drugs, Fourth Edition, eds., R Levy, RH Mattson, B Meldrum, Raven Press, New York, 621-631, 1995.

Mattson RH, Cramer JA. The choice of antiepileptic drugs in focal epilepsy. In: The Treatment of Epilepsy, Second Edition, ed., E Wyllie, Williams and Wilkins, Baltmore, 771-778, 1996.

Mattson RH. Carbamazepine. In: Epilepsy, a Comprehensive Textbook. eds., T Pedley, J Engel, Raven Press, New York, 1996.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Low brain GABA and high glutamate correlate with poor seizure control in patients with with complex partial epilepsy. In: The Third International Symposium on Basic Mechanisms of the Epilepsies. eds., AV Delgado-Escueda , W Wilson , RW Olsen , RJ Porter. 374-378, 1996.

Porter R, Mattson, RH. Alcohol and Drug Abuse. In: Epilepsy, a Comprehensive Textbook. eds., T Pedley, J Engel, Raven Press, New York, 1997.

Petroff OAC, Behar KL, Rothman DL, Mattson RH. Patients with complex partial seizures have increased occipital glutamate and glutamine. In Proceedings of the International Society of Magnetic Resonance in Medicine, Vol 1, International Society of Magnetic Resonance in Medicine, Berkeley, California 1997, p34.

Mattson RH, Scheyer RD, Petroff OAC, During M, Collins TL, Spencer DD. Novel methods for studying new antiepileptic drug pharmacology. In Advances in Neurology 1998; 76: 105 112.

Petroff OAC, Hyder F, Collins TL, Mattson RH, Rothman DL. Topiramate increases brain GABA, homocarnosine, and Pyrrolidinone in patients with epilepsy. Neurology 1999; 52: 473 478.

Cramer JA, Fisher R, Ben-Menacham E, French J, Mattson RH. New antiepileptic drugs: Comparison of key clinical trials. Epilepsia 1999; 40(5): 590-600.

Petroff OAC, Rothman DL, Behar KL, Hyder F, Mattson RH. Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine and GABA in patients with refractory complex partial seizures.
Seizure 1999; 8: 120-127.

Hyder F, Petroff OAC, Mattson RH, Rothman DL. Localized 1H NMR measurements of 2 pyrrilodinone in patients with epilepsy. Magnetic Resonance Medicine 1999; 41: 889-896.

Petroff OAC, Hyder F, Collins TL, Mattson RH, Rothman DL. Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures. Epilepsia 1999; 40: 958-964.

Verhoeff NPLG, Petroff OAC, Hyder F, Zoghbi SS, Fujita M Rjeevan N, Collins TL, Seibyl J, Mattson RH, Innis R. Effects of vigabatrin on the GABA-ergic system as determined by iomazenil SPECT and GABA MRS. Epilepsia 1999; 40: 1433-1438

Mattson RH, Bickford R. Firing patterns of bilateral strychnine spikes in the cortex of the cat. EEG Clin Neurophysiol 13:144-145, 1961.

Abstracts

Mattson RH, Heninger GR, Gallagher BB, Glaser GH. Psychophysiologic precipitants of seizures in epileptics. Neurology 20:407, 1970.

Glass DH, Mattson RH. Psychopathology and emotional precipitation of seizures in temporal lobe and nontemporal lobe epileptics. Proceedings of the 81st Annual Convention of the American Psychological Association, 425-426, 1973.

Glass DH, Mattson RH. Paroxysmal EEG activity during fixed-ratio and DRL performance of temporal lobe epileptics. EEG Clin Neurophysiol 37:204, 1974.

Mattson RH. Subacute sclerosing panencephalitis recovery associated with isoprinosine therapy: Report of a case. Neurology 24:383, 1974.

Mattson RH, Lerner E, Dix G. Precipitating and inhibiting factors in epilepsy: A statistical study. Epilepsia 15:271-272, 1974.

Eisler J, Mattson RH. Compliance in anticonvulsant drug therapy. Epilepsia 15:203, 1975.

Cramer JA, Mattson RH, Brillman J. Folinic acid therapy in epilepsy. Fed Prac 35:582, 1976.

Williamson PD, Allison TJ, Goff WR, Mattson RH. Evoked potential abnormalities in epilepsy: The e-wave. EEG Clin Neurophysiol 42:729-730, 1977.

Kuhlman WN, Mattson RH. Electroencephalographic feedback training in the treatment of seizures. Mechanism and maintenance of effect. Biofeedback Self-Regul 4:267, 1979.

Cramer JA, Mattson RH. Central case validation. Controlled Clin Trials 1:168, 1980.

Cramer JA, Collins JF, Mattson RH, the VA Epilepsy Cooperative Study Group. Which patient will be lost in follow-up? Controlled Clin Trials 2:78, 1981.

Cramer JA, Mattson RH. Cinromide pharmacokinetics and interactions. Epilepsia 22:235, 1981.

Mattson RH, Kamer JM, Cramer JA, Caldwell BV. Seizure frequency and the menstrual cycle: A clinical study. Epilepsia 22:242, 1981.

Mattson RH, the VA Cooperative Study Group. Agreement among EEG readers. EEG Clin Neurophysiol 53:300, 1982.

Cramer JA, Collins JF, Mattson RH, the VA Epilepsy Cooperative Study Group. What happens to study dropouts? Controlled Clin Trials 5:307, 1984.

Cramer JA, Mattson RH, Bennett DM. Utilization of free valproic acid determinations. Clin Pharmacokinet 9:94-95, 1984.

Cramer JA, Mattson RH, Collins JF, Browne TF, the VA Epilepsy Cooperative Study Group. Correlation between phenytoin and carbamazepine free fraction and serum albumin. Epilepsia 25:674-675, 1984.

Mattson RH, Cramer JA, Toftness BR, Mebust K. Testosterone and antiepileptic drugs. Epilepsia 26:538, 1985.

Cramer JA, Mattson RH, Wannamaker B, et al. Reliability of immunochromatographic assay for phenobarbital and phenytoin. Epilepsia 27:621-622, 1986.

Curley A, Delaney RC, Mattson RH. Behavior problems in children with seizures and their relation to parental influences. Epilepsia 27:615, 1986.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Connective tissue changes, hypersensitivity rash and blood laboratory test changes associated with antiepileptic drug therapy. Ann Neurol 20:119-120, 1986.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Etiology of partial epilepsy in 622 adults. Epilepsia 27:618, 1986.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Side effects of carbamazepine, phenobarbital, phenytoin and primidone. Neurology 36:325, 1986.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Success with alternate antiepileptic drug selection. Epilepsia 27:645, 1986.

Mattson RH, Cramer JA, Toftness BR, Mattson GF. Postictal changes in prolactin and luteinizing hormone. Neurology 36:444, 1986 (letter).

Cramer JA, Collins JF, Mattson RH, the VA Epilepsy Cooperative Study Group. Reasons for non-drug related loss to a multicenter epilepsy study. Controlled Clin Trials 8:306, 1987.

Mattson RH, Cramer JA, Siconolfi BC, Toftness BR, Swick CS. Successful valproate monotherapy for generalized tonic clonic seizures. Epilepsia 28:627, 1987.

Mattson RH, Toftness BR, Cramer JA. Postictal pituitary hormonal changes. Neurology 37(Suppl 1):100-101, 1987.

Cramer JA, Prevey ML, Ouellette V, Mattson RH. Can non-compliance be predicted? Epilepsia 29(Suppl 5): 705, 1988.

Delaney RC, Prevey ML, Mattson RH, Cramer JA. Test-retest comparability and control subject data for the PASAT, Rey-AVLT, and Rey-Osterrieth/Taylor Figures. J Clin Exp Neuropsychol 10(Suppl 1):44, 1988.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Time of next seizure after starting an antiepileptic drug. Epilepsia 29(Suppl 5):704, 1988.

Mattson RH, Cramer JA, Toftness B. Prolactin changes following temporal and extra temporal seizures of varying severity. Epilepsia 29(Suppl 5):704, 1988.

Prevey ML, Delaney RC, Mattson RH, Cramer JA. Cognitive functioning in seizure patients prior to treatment with antiepileptic drugs. Epilepsia 29(Suppl 5):692, 1988.

Ramsay RE, Wilder BJ, Mattson RH, et al. Conversion of polytherapy to valproate monotherapy in patients with tonic clonic seizures. Epilepsia 29(Suppl 5):699, 1988.

Schwartz SS, Spencer DD, Novelly, RA, Spencer SS, Sass KJ, Williamson PD, Mattson RH. Preservation of verbal and pictorial memory after anteromedial temporal lobectomy and radical hippocampectomy for temporal lobe epilepsy. Epilepsia 29(Suppl 5):677, 1988.

Delaney RC, Prevey ML, Mattson RH. Memory scanning and material-specificity with lateralized temporal lobe epilepsy. J Clin Exp Neuropsychol 11(Suppl 1):48-49, 1989.

Mattson RH, Cramer JA, Collins JF, the VA Epilepsy Cooperative Study Group. Analysis of seizure recurrence by etiology. Neurology 39(Suppl 1):148, 1989.

Scheyer RD, Cramer JA, Toftness B, Mattson RH. Valproate related tremor. Epilepsia 30:639, 1989.

Schumacher GE, Barr JT, Browne TR, the VA Epilepsy Cooperative Study Group (Mattson RH). Using decision analysis to study the usefulness of the serum phenytoin concentration (SPC). Clin Pharmacol Ther 45:152, 1989.

Cramer JA, Scheyer RD, Hochholzer JM, Mattson RH, the VA Cooperative Study Group. Carbamazepine assay cross-reactivity. Neurology 40(Suppl 1):138, 1990.

Delaney RC, Prevey ML, Mattson RH. Long term recall following learning to criterion in focal temporal lobe epilepsy. J Clin Exp Neuropsychol 12(Suppl 1):87, 1990.

Mattson RH, Cramer JA, the VA Epilepsy Cooperative Study Group. Seizure remission after active epilepsy. Epilepsia 31:648, 1990.

Prevey ML, Cramer JA, Delaney RC, Mattson RH. Behavioral toxicity battery for antiepileptic drug trials. Epilepsia 31(Suppl 5):656, 1990.

Prevey ML, Delaney RC, Tice DM, Mattson RH. Map learning in temporal lobe seizure patients. J Clin Exp Neuropsychol 12(Suppl 1):87, 1990.

Scheyer RD, Cramer JA, Mattson RH, the VA Epilepsy Cooperative Study Group 118. Outpatient bayesian non-steady state phenytoin predictions. Epilepsia 31:599, 1990.

Spencer SS, Guimaraes P, Katz A, Spencer DD, Mattson RH. Morphological characteristics of seizure onset from intracranial recording. Epilepsia 31:663, 1990.

Cramer JA, Mattson RH, Scheyer RD. Diagnosis of seizure precipitants using medication monitors. Neurology 41(Suppl):366, 1991.

Cramer JA, Scheyer RD, Hochholzer JM, Mattson RH, the VA Epilepsy Cooperative Study Group 264. Carbamazepine concentrations and adverse effects. Epilepsia 32:14, 1991.

Delaney RC, Prevey ML, Tice DM, Mattson RH. A further investigation of the short term memory deficit in lateralized seizure patients: Release from proactive interference. J Clin Exp Neuropsychol 13(Suppl 1):42, 1991.

Prevey ML, Delaney RC, Cattanach L, Mattson RH. Prediction of memory in temporal and extratemporal seizure patients. J Clin Exp Neuropsychol 13(Suppl 1):41, 1991.

Cramer JA, Mattson RH, the VA Epilepsy Cooperative Study Group 264. Laboratory test abnormalities during long-term use of carbamazepine and valproate. Neurology 42(Suppl 3):331, 1992.

Kocsis JD, Mattson RH, Oyelese AA. Modulation of CA1 hippocampal neuronal excitability by ingibition of GABA uptake with nipecotic acid. Society for Neuroscience Abstract, 1992.

Mattson RH, Cramer JA, the VA Epilepsy Cooperative Study Group. Seizure remission in adults with epilepsy. Neurology 42(Suppl 3):243, 1992.

Prevey ML, Delaney RC, Cramer JA, Mattson RH, Collins JF, Cattanach L, the VA Cooperative Study Group 264. Valproate versus carbamazepine: Comparison of effects on cognitive functioning. Epilepsia 33(Suppl 3):110, 1992.

Cramer JA, Mattson RH, the VA Epilepsy Cooperative Studies 118 and 264 Groups. Control of complex partial and tonic-clonic seizures for one year after starting treatment. Epilepsia 34(Suppl 6):50, 1993.

Cramer JA, Mattson RH, the VA Epilepsy Cooperative Studies 118 and 264 Groups. Same prognosis for seizure control for patients grouped by pure or predominant seizure type. Epilepsia 34(Suppl 6):50, 1993.

During M, Mattson RH, Scheyer RD, Rask C, Pierce M, McKelvy J, Thomas V. The effect of tiagabine HCI on extracellular GABA levels in the human hippocampus. Epilepsia(Suppl 3):83, 1993.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Estimates of the rate of GABA synthesis in patients with epilepsy. In: Proceedings of the International Society of Magnetic Resonance in Medicine Vol 2, Society of Magnetic Resonance, Berkley, California 1996, p962.

Petroff, OAC, RothmanDL, Behar KL, Mattson RH. Low brain GABA is associated with poor seizure control in patients with complex partial epilepsy. In: Proceedings of the International Society of Magnetic resonance in Medicine Vol 1, Society of Magnetic Resonance, Berkley, California 1996, p131.

Petroff OAC, Rothman DL, Behar KL, Collins TL Mattson RH. The acute effects of vigabatrin on brain GABA concentration in patients with intractable epilepsy. Neurology 46(Suppl): A227, 1996.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Human brain GABA is the same on standard and high dose vigabatrin. Journal of Neurochemistry 66(Suppl 1):S82, 1996.

Mattson RH, Petroff OAC, Rothman DL, Behar KL, Collins TL. Oral vigabatrin raises human brain GABA within two hours. Epilepsia 1996: 37 (suppl 5): 203.

Petroff OAC, Rothman DL, Behar KL, Mattson RH. Low Brain GABA is associated with frequent seizures. Epilepsia 1996: 37 (suppl 5):

.Scheyer RD, Assaf BA, Spencer SS, Mattson RH. Gabapentin Related Myoclonus. Epilepsia 1996; 37 (suppl 5)

Petroff OAC, Mattson RH, Behar KL, Hyder F, Rothman DL. Vigabatrin increases human brain homocarnosine and improves seizure control. Epilepsia 1997; 38 (suppl 8)

Petroff OAC, Hyder F, Rothman DL, Collins TL, Mattson RH. Gabapentin increases human brain GABA within one hour. Epilepsia 1998;39 (suppl 6)

Collins TL, Petroff OAC, Mattson RH. Comparison of new antiepileptic drug therapy. Epilepsia 1998;39 (suppl 6):59-60.

Petroff OAC, Hyder F, Collins TL, Mattson RH, Rothman DL. Acute effects of vigabatrin on brain GABA and homocarnosine. Ann Neurol 1998;44:498.

Petroff OAC, Hyder F, Behar KL, Mattson RH, Rothman DL. Increased homocarnosine is associated with improved seizure control. In proceedings of the International Society of Magnetic Resonance in Medicine, Vol 1, International Society of Magnetic Resonance in Medicine, Berkeley, California 1998, p287.

Williamson PD, Thadani VM, French JA, Darcey TM, Mattson RH, Spencer SS, Spencer DD. Medial temporal lobe epilepsy: Video tape analysis of objective clinical seizure characteristics. Epilepsia 1999; 39(11): 1182

Gautam RM, Walid AS, Mattson RH, Kocsis JD. Gabapentin and vigabatrin enhance promoted GABA release in rat hippocampus in vivo. Epilepsia, vol. 40, Suppl. 7, 1999.

Petroff, OAC, Hyder F, Collins TL, Rothman DL, Mattson RH. Vigabatrin increases brain GABA within one hour. Epilepsia, Vol. 40, Suppl. 7, 1999.


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