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L. James Willmore, M.D. Associate Dean Email: willmore@slu.edu Bachelor of Science, Saint Louis University, 1964 Doctor of Medicine, cum laude, Saint Louis University Intern in General Surgery, Saint Louis University Hospitals Assistant Resident in Neurology Fellow in Neurochemistry Chief Resident in Neurology Assistant Professor of Neurology Assistant Professor of Neuroscience Graduate Faculty, University of Florida Associate Professor of Neurology and Associate Professor of Neurology Graduate Faculty, Professor of Neurology Professor of Neurology Associate Dean - Admissions Associate Dean - Student Affairs Professor of Pharmacology and Physiology Director, Office of Continuing Medical Education Lieutenant, United States Navy, Medical Officer, U.S.S. Austin (LPD-4), 1969-70 Physician, Division of Internal Medicine Honorable Discharge as Lieutenant Commander, Staff Neurologist, Veterans Administration Medical Center, Project Supervisor, Epilepsy Diagnostic Director, Electroencephalography Laboratory Attending Neurologist, Shands Teaching Hospital, Attending Neurologist, Hermann Hospital Acting Director, Clinical Neurophysiology Laboratory, Director, Clinical Neurophysiology Laboratory, Consultant in Neuro-Oncology National Board of Medical Examiners, 1969 Certified in Neurology by the American Board of Psychiatry and Neurology #15844, 1976 Certified in Clinical Neurophysiology by the American Board of
Psychiatry and Neurology #757, 1996 American Academy of Neurology, American Electroencephalographic Society, 1975 Thurston Scholastic Award, 1965- Journal of Brain Science Neurosciences Experimental Neurology Residential Care Committee, Department of Health, Education, and Welfare Commission on Epilepsy and its Consequences, 1976-77 Veterans Administration Epilepsy Education Task Force, 1980-82 Chairman, National Institutes of Health Neurological Sciences I Study Section, ad hoc committee, July 1985 Epilepsy Foundation of America: National Institutes of Health (NINCDS) Technical Merit Review Study Section #2, 1981-89 National Institutes of Health (NINCDS) Participant, Special Workshop on Prophylaxis of Posttraumatic Epilepsy-1990 American Board of Psychiatry and Neurology Examiner 1980- Member, National Merit Review Board: Alcoholism Drug Dependence, Clinical Pharmacology 1993-1995 Department of Veterans Affairs Washington, D.C. J. Kiffin Penry Fellowship Member, National Institutes of Health NINCDS Neurological Sciences
Special Projects Study Section 1998-1999 National Institutes of Health. NIH RO1 NS-16704 Prevention of experimental posttraumatic epilepsy. 2/81-3/84. Principal Investigator. Veterans Administration Research Service, Neurochemistry of posttraumatic epilepsy. 7/81-6/83 (terminated with University of Texas appointment).Principal Investigator. VA Research Service, Neurochemistry of posttraumatic epilepsy. 7/78-6/82. Principal Investigator. Texas Epilepsy Center-Program for Advanced Studies of Epilepsy 7/86-1/99 Principal Investigator. National Institutes of Health. NIH RO1 NS 32786-01A1 NSPA National
acute brain injury study: Hypothermia. 4/94-3/98. Co-Principal Investigator.
Double-blind assessment of Nitrazepam as add-on therapy in patients with generalized seizures. Abbott Laboratories Division of Clinical Research Co-investigator 1975-1977 Open label add-on treatment with Valproic Acid in patients with absence seizures. Abbott Laboratories Division of Clinical Research Co-investigator 1977-1979 Treatment of Complex Partial Seizures. Ciba-Geigy Pharmaceutical Principal Investigator 1980 1981 Double-blind placebo-controlled addition of Lamotrigine to patients with intractable partial seizures. Burroughs-Wellcome Laboratories Principal Investigator 1986-1995 Double-blind, placebo-controlled high dose addition of Topiramate to the treatment of patients with intractable seizures. McNeil Pharmaceuticals; Principal Investigator 1988-1995 Comparison of valproate and carbamazepine in the treatment of complex partial seizures. Abbott Laboratories Division of Clinical Research Principal Investigator 1989-1992 Comparison of Felbamate with valproate in patients with partial seizures. Carter Wallace Laboratories Principal Investigator 1989-1992 Use of intravenous Valproate as equivalent dose substitution. Abbott Laboratories Principal Investigator 1991-1993 Assessment of intravenous Lorazepam in the treatment of status epilepticus. Ayerst Laboratories Principal Investigator 1992-1994 Zonisamide Study in patients with uncontrolled partial seizures Dianippon Pharmaceuticals Principal Investigator 1993-1996 Efficacy and safety of UCB-LO59 in patients with complex partial seizures. UCB Pharmaceuticals. Principal Investigator 1995-1999 Efficacy and safety of SKB in patients with partial onset seizures. SmithKline Laboratories. Principal Investigator 1996-1999 Add-on placebo controlled study of Pregabalin in patients with
partial seizures. Parke-Davis. Principal Investigator 1998-2000. 1. Willmore, L.J., Fuller, P.M., Bass, N.H.: Acute focal epileptiform discharge induced by pial surface iontophoresis of cobalt chloride: Microchemical, morphologic, and electro encephalographic observations. Neurology 24:379, 1974. 2. Willmore, L.J., Butler, A.B., Fuller, P.M., Bass, N.H.: Laminar ATPase changes at initiation of cobalt-induced cortical epileptiform discharge. Proc. American Epilepsy Society December, 1975. 3. Wilder, B.J., Ramsay, R.E., Willmore, L.J., Shumate, J., Feussner, G.: Therapy of status epilepticus with diphenylhydantoin: Pharmacokinetics and CNS penetration during IV infusion. Proc. American Epilepsy Society December, 1975. 4. Ramsay, R.E., Wilder, B.J., Strauss, R., Willmore, L.J.: Status epilepticus during pregnancy: Effects of gastrointestinal malabsorption of phenytoin kinetics and seizure control. Neurology 26:344, 1976. 5. Butler, A.B., Willmore, L.J., Bass, N.H.: Acute focal epileptiform discharge induced by pial iontophoresis of cobalt chloride: Ultrastructural observations. Anatomical Record 184:368, 1976. 6. Ramsay, R.E., Wilder, B.J., Willmore, L.J., Perchalski, R.J.: Central nervous system penetration of anticonvulsant drugs. Epilepsia 18:290, 1977. 7. Willmore, L.J., Wilder, B.J., Ramsay, R.E.: Effect of trimethadione and ethosuximide on bicuculline-induced seizures. Epilepsia 18:292, 1977. 8. Willmore, L.J., Sypert, G.W., Munson, J.B.: Epileptiform discharge induced by ferrous and ferric cations. Neuroscience Abstracts 3:148, 1977. 9. Ramsay, R.E., Strauss, R., Wilder, B.J., Willmore, L.J., Perchalski, R.J.: Phenytoin kinetics and seizure frequency during pregnancy. Excerpta Medica 130, 1977. 10. Bass, N.H., Willmore, L.J., Butler, A.B.: Cobalt-induced epileptiform discharge: Possible utility of this experimental model in a search for new forms for anticonvulsant therapy. Annals of Neurology 2:263, 1977. 12. Villarreal, H.J., Bauman, A.W., Hammond, E.J., Wilder, B.J.,
Willmore, L.J.: The effect of valproate on spike and wave discharges. Neurology
28:351, 1978. 14. Wilder, B.J., Bruni, J., Willmore, L.J., Villarreal, H.J.: Clinical experience with valproic acid. Canadian Journal of Neurological Sciences 5:347, 1978. 15. Pinnas, R.M., Willmore, L.J.: Assessment of altered behavioral function in epileptics. Proc. Epilepsy International Symposium, 222, 1978. 16. Willmore, L.J., Sypert, G.W.: Experimental post-traumatic epilepsy: Neurochemical, morphologic and EEG observations. Proc. Epilepsy International Symposium, 211, 1978. 17. Willmore, L.J., Dunn, A.J., Rubin, J.J.: Altered protein synthesis within a recurrent seizure focus in the albino rat. Neuroscience Abstracts 4:148, 1978. 18. Reid, S.A., Boggs, W.M., Sypert, G.W., Willmore, L.J.: Histopathology of ferric-induced epileptogenic foci: A golgi survey in cats. Neuroscience Abstracts 4:147, 1978. 19. Boggs, W.M., Reid, S.A., Sypert, G.W., Munson, J.B., Willmore, L.J.: Chronic iron-induced epileptogenic foci: An electrophysiological study in rats. Neuroscience Abstracts 4:139, 1978. 20. Sypert, G.W., Willmore, L.J.: A new model of post-traumatic epilepsy: Iron cations. Proc. Congress Neurological Surgeons 28:110-112, 1978. 21. Wilder, B.J., Ramsay, R.E., Willmore, L.J.: Efficacy of intravenous phenytoin in treatment of status epilepticus: Kinetics of central nervous system penetration. World Epilepsy 4:4, 1978. 22. Willmore, L.J., Wilder, B.J., Bruni, J.: Effect of valproic acid on hepatic function. Modern Medicine 27:127, 1979. 23. Bruni, J., Wilder, B.J., Willmore, L.J.: Clinical efficacy of valproic acid in relation to plasma levels. Epilepsy World 5:1, 1979. 24. Villarreal, H.J., Wilder, B.J., Willmore, L.J.: Effects of valproic acid on spike-and-wave discharges in patients with absence seizures. Epilepsy World 5:2-3, 1979. 25. Willmore, L.J., Sypert, G.W., Munson, J.B.: Recurrent seizures induced by cortical iron injection: A model of post-traumatic epilepsy. Epilepsy World 5:7, 1979. 26. Butler, A.B., Willmore, L.J., Sypert, G.W.: Chronic iron-induced epileptogenic foci: An ultrastructural study in rats. Neuroscience Abstracts 5:189, 1979. 27. Wilder, B.J., Willmore, L.J.: Valproic acid: Interaction with other anticonvulsant drugs. Epilepsy World 5:15, 1979. 28. Willmore, L.J., Heilman, K.M.: Effect of chronic seizures on religiosity. Annals of Neurology 8:97, 1980. 29. Willmore, L.J., Rubin, J.J.: Prevention of experimental post-traumatic epilepsy in rats by treatment with antiperoxidants. Neurology 30:355, 1980. 30. Bruni, J., Wilder, B.J., Willmore, L.J., Villarreal, H.J.: Long-term effects of valproic acid on spike and wave discharges. EEG, Clinical Neurophysiology 49:14P, 1980. 31. Bruni, J., Wilder, B.J., Willmore, L.J., Villarreal, H.J.: Long-term effects of valproic acid on spike and wave discharges. EEG, Clinical Neurophysiology 49:74P, 1980. 32. Willmore, L.J.: Role of superoxide radicals and lipid perioxidation in the development of experimental post-traumatic epilepsy. Proceedings Epilepsy International Congress, pp. 30-31, 1981. 33. Willmore, L.J., Rubin, J.J.: Prevention of FeCl2 induced lipid peroxidation in rate isocortex by pretreatment with antiperoxidants. Neurology 32:A154, 1982. 34. Willmore, L.J., Triggs, W.J.: Effect of phenytoin, tocopherol and corticosteroid treatment on iron-induced lipid peroxidation in rat isocortex. Annals of Neurology 14:153, 1983. 35. Willmore, L.J., Triggs, W.J.: Kindled seizures induced by injection of FeCl2 into rat amygdala. Neurology 34:s126, 1984. 36. Willmore, L.J., Triggs, W.J.: Prevention of neural lipid peroxidation by DL-alpha- tocopherol alcohol. Neurology 34:s196, 1984. 37. Triggs, W.J., Willmore, L.J., Bohan, T.P., Lin, S-N: Valproate-induced mitochondrial encephalopathy with ketosis and adipic aciduria. Annals of Neurology 26:161, 1989. 38. Bohan, T.P., Triggs, W.J., Willmore, L.J., Lin, S-N: Valproate-induced
mitochondrial encephalopathy with ketosis and adipic aciduria. Annals of Neurology
26:455-456, 39. Triggs, W.J., Hanson, S.K., Willmore, L.J.: Adult multiple acyl-CoA dehydrogenation defect: altered behavior and valproate induced coma. Neurology 40:139, 1990. 40. Triggs, W.J., Hanson,S.K., Willmore, L.J.: Adult multiple acyl-CoA dehydrogenation defect: Altered behavior and valproate induced coma. Annals of Neurology 28: 264-265, 1990. 41. Triggs, W.J., Yeakley, J.B., Willmore, L.J., Janus, T.J., Levy, B.A.: Acute and convalescent MRI in puerperal seizures. Annals of Neurology 28:264-265, 1990. 42. Wheless, J.W., Kramer, L., Combs-Cantrell, D.T., Willmore, L.J., Gildenberg, P., Rosen, W.D., Brookshire, B.L., Fletcher, J.M. Role of Gadolinium-DTPA-enhanced magnetic resonance imaging in pediatric presurgical evaluation for intractable partial epilepsy. Epilepsia 32:s81, 1991. 43. Combs-Cantrell, D.T., Wheless, J.W., Willmore, L.J., Fletcher, J.M., Rosen, W.D., Brookshire, B.L. Transient magnetic resonance imaging focal abnormalities associated with complex partial status epilepticus in childhood. Epilepsia 32:s81, 1991. 44. Wheless, J.W., Kramer, L., Combs-Cantrell, D.T., Willmore, L.J., Gildenberg, P., Rosen, W.D., Brookshire, B.L., Fletcher, J.M. Role of Gadolinium-DTPA-enhanced magnetic resonance imaging in pediatric presurgical evaluation for intractable partial epilepsy. Annals of Neurology 30:494, 1991. 45. Galan, J.A., Anderson, A.E., Yeakley, J.W., Curtis, V.L., Wheless, J.W., Willmore, L.J. MELAS-associated status epilepticus: Metabolic intervention and treatment-resistant seizures. Epilepsia 33: 5, 1992. 46. Willmore, L.J., Wheless, J.W., Curtis, V.L., Barron, B.J., Tran, H.D., Fletcher, J.M. SPECT abnormalities in patients with nonepileptic seizures. Epilepsia 33: 53-54, 1992. 47. Abi-Said, D., Annegers, J.F., Cantrell, D.C., Willmore, L.J. Case-control study for the risk factors for eclampsia. Epilepsia 33: 57, 1992. 48. Messenheimer, J., Ramsay, R.E., Leroy, R.F., Zielinski, J.J., Willmore, L.J., Pellock, J.M., Mattson, R., Rudd, G.D., Keaney, P.A. Multicenter, long-term study of Lamotrigine (Lamictal) in outpatients with partial seizures. Epilepsia 33:82, 1992. 49. Curtis, V.L., Wheless, J.W., Willmore, L.J. Equivalent sensitivity between a non-invasive scalp montage and sphenoidal electrodes. Epilepsia 33:90, 1992. 50. Willmore, L.J., Curtis, V.L., Oelberg, D.G., Wheless, J.W. Infertility secondary to valproate therapy. Epilepsia 33:108, 1992. 51. Wheless, J.W., Duke-Woodside, M., Kramer, L.A., Bohan, T., Slopis, J., Butler, I.J., Willmore, L.J. Magnetic resonance imaging in infantile spasms: Implication for epilepsy surgery. Epilepsia 33:113, 1992. 52. Wheless, J.W., Galan, A., Barron, B.J., Tran, H.D., Willmore, L.J., Curtis, V.L., Lamki, L.M. Nonepileptic seizures: Diagnostic verification with ictal and interictal SPECT. Epilepsia 34:140, 1993 53. Willmore, L.J., Leavens, T., Curtis V.L., Wheless, J.W., Roongta, S.M. Pentobarbital Coma: Treatment duration criteria and monitoring strategy. Epilepsia 34:52, 1993. 54. Curtis, V.L., Thomas, A.B., Wheless, J.W., Willmore, L.J., Galan, J.A., Martinez, H. Initiation and tolerance of intravenous valproic acid in children. Epilepsia 34:81-82 1993. 55. Thomas, A.B., Curtis, V.L., Wheless, J.W., Willmore, L.J., Galan, J.A., Martinez, H. Initiation and tolerance of intravenous valproic acid. Epilepsia 34:98, 1993. 56. Curtis, V.L., Galan, J.A., Barron, B.J., Thomas, A.B., Wheless, J.W., Willmore, L.J. Correlation of EEG with ictal SPECT flow patterns using stabilized Ceretec. Epilepsia 34:100,1993. 57. Penry, J.K., Wilder, B.J., Sachdeo, R.C., Vaughan, L.U., Ahlbrandt, R.A., Sommerville, K.W., Sussman, N.M., Yerby, M.S., Willmore, L.J., et al. Multicenter dose-response study of Vigabatrin in adults with focal (partial) epilepsy. Epilepsia 34:67, 1993. 58. Tran, H., Lamki, L.M., Barron, B., Wheless, J., Willmore, J., Curtis, V. Tc-99m- examination on non-epileptic (pseudo) seizures. Nuclear Medicine 18:176, 1993. 59. Willmore, J., Brugger, A., Shu, V. Depakote in the treatment of complex partial seizures. Neurology 44: (Suppl 2) A295, 1994. 60. Devinsky, O., Leppik, I., Willmore, L.J., Pellock, J.M., Dean, C., Gates, J. Safety of intravenous valproate. Epilepsia 35: 144, 1994. 61. Lamki, L.M., Wheless, J.W., Barron, B.B., Curtis, V.L., Willmore, L.J. Clinical trial of Tc- 99m bicisate (ECD) Ictal and interictal brain SPECT in evaluation for surgical treatment of epilepsy: Findings compared with temporal variations in normal controls. Radiology, 1994. 62. Plenger, P.M., Breier, J.I., Wheless, J.W., Brookshire, B.L., Papanicolaou, A.C., Thomas, A.B., Willmore, L.J. The utility of the MMPI in differentiating non-epileptic seizure disorder from frontal lobe epilepsy. Epilepsia 36:136, 1995. 63. Breier, J.I., Plenger, P.M., Wheless, J.W., Brookshire, B.L., Curtis, V.L., Papanicolaou, A.C., Thomas, A.B., Willmore, L.J. Evidence for re-organization of spatial and figural memory following early seizure activity. Epilepsia 36: 132, 1995. 64. Puduvalli, V.K., Wheless, J.W., Thomas, A., Willmore, L.J., Curtis, V.L. Magnetoencephalography/Magnetic source imaging in seizure focus localization and postsurgical outcome Prediction in patients with intractable epilepsy. Neurology 46: A124, 1996. 65. Ray, P.G., Meador, K.J., Smith, J.R., Sittenfeld, O.M., Wheless, J.W., Thomas, A.B., Willmore, L.J., Clifton, G. The human somatosensory cortex and the physiology of perception. Neurology 46: A127, 1996 66. Plenger, P.M, Breier, J.I., Brookshire, B.L., Wheless, J.W., Thomas, A.B., Papanicolaou, A.C., Willmore, L.J. Enhancing discrimination of left temporal lobe epilepsy during the intracarotid sodium amobarbital procedure. Epilepsia 37:133, 1996. 67. Willmore, L.J., Morrell, M.J., McLean, M.J., Magnus-Miller, L., Podolnick,P.B., Rose Legatt, A. The role of phase IV studies in assessment of newly available antiepileptic drugs: the example of Neurontin. Epilepsia 37:157, 1996. 68. Breier, J.I., Thomas, A.B., Mullani, N., Plenger, P.M., Wheless, J.W., Willmore, L.J. Effects of age at onset and duration of chronic seizure disorder on asymmetries in temporal lobe metabolism and blood flow in complex partial epilepsy. Epilepsia 37:197, 1996. 69. Schacter, S.C., Vazquez, B., Fisher, R.S., Laxer, K.D., Cantrell, D.T., Montouris, G.D., Faught, E., Willmore, L.J., Ojemann, L.M., Morris, G.L., Bennett, D.A. Monotherapy trial of oxcarbazepine for partial seizures in hospitalized presurgical patients. Epilepsia 37: 202, 1996. 70. Morrell, M., McLean, M.J., Willmore, L.J., Magnus-Miller, L., Podolnick, P.B., Rose Legatt, A. Efficacy of Gabapentin (Neurontin) as add-on therapy for patients with partial epilepsy. Neurology 48: 335, 1997. 71. McLean, J.J., Willmore, L.J., Morrell, M., Privitera, M.D., Holmes, G.L., Faught, R.E., Magnus-Miller, L., Podolnik, P.B. Efficacy of Gabapentin (Neurontin) as add on therapy for patients older than 60 years with partial seizures. Epilepsia 38: 65, 1997. 72. Fuchs, K.L., Breier, J.I., Caudle, D.D., Brookshire, B.B., Thomas, A.B., Wheless, J.W., Constantinou, J., Papanicolauo, A., Willmore, L.J. The effect of language lateralization on recognition memory performance during the Wada test. Epilepsia 38: 211, 1997. 73. Willmore, LJ, Wheless, JW, Breier, JI, Kataki,M., Smith, JR, King, DW, Meador, JK, Park,YD, Loring DW, Clifton, GL, Baumgartner, J, Thomas, AB. A comparison of magnetoencephalography (MEG), MRI, and V-EEG in patients evaluated for epilepsy surgery. Epilepsia 39: 64-65, 1998 74. Papanicolaou, A.C., Breier, J.I., Gromley,W.B., Simos, P.G., Wheless, J.W., Constantinou, J.E.C., Willmore, L.J. Comparison of language mapping using extra- and intraoperative electrocortical stimulation and magnetoencephalography. Epilepsia. 39: 107-108, 1998. 75. Schacter, S.C., Vazquez, B., Fisher, R.S., Laxer, K.D., Cantrell, D.T., Montouris, G.D., Faught, E., Willmore, L.J., Ojemann, L.M., Morris, G.L., Bennett, D.A., Mesenbrink, P., D'Souza, J., Kramer, L. Oxcarbazepine: A double-blind, randomized, placebo control, monotherapy trial for partial seizures. Neurology 1999. 76. Doi, T., Ueda, Y., Tokumaru, J., Mitsuyama, Y., Willmore, L.J. Expression of NMDA and AMPA glutamate receptors during development of chronic seizures following amygdalar FeCl3 injection. Epilepsia 41: 8, 2000. 77. Doi, T., Ueda, Y., Tsuru, N., Tanaka, K., Tokumaru, J., Mitsuyama, Y., Willmore, L.J. Ionotropic glutamate receptor expression in GLAST knockout mice. Epilepsia 41: 27, 2000. 78. Ueda, Y., Willmore, L.J. Mechanism of action of valproic acid: Molecular regulation of glutamate and GABA transporter proteins. Epilepsia 41:12-13, 2000. 79. Ueda, Y., Doi, T., Tokumaru, J., Mitsuyama, Y., Willmore,
L.J. Collapse of glutamate regulation in rat hippocampus correlates with chronic
epileptogenesis. Epilepsia 41:51, 2000. 1. Willmore, L.J., Smith, K.: Intracerebral metastatic hypernephroma appearing 17 years postnephrectomy: A case report. Missouri Medicine 66:883, 1969. 2. Willmore, L.J., Fuller, P.M., Butler, A.B., Bass, N.H.: Neuronal compartmentation of ionic cobalt in rat cerebral cortex during initiation of epileptiform activity. Experimental Neurology 47:280-289, 1975. 3. Butler, A.B., Willmore, L.J., Fuller, P.M., Bass, N.H.: Focal alteration of dendrites and astrocytes in rat cerebral cortex during initiation of cobalt-induced epileptiform discharge. Experimental Neurology 51:216-229, 1976. 4. Willmore, L.J.: Seizures complicated by coma in the elderly. Geriatrics 31:112-114, 1976. 5. Willmore, L.J., Wilder, B.J., Ramsay, R.E.: "Episodic Loss of Consciousness: Syncope, Seizures, and Narcolepsy." In: Clinical Concepts of Neurology (Eds.) L.E. Cluff, M.D. and J.E. Johnson, M.D., Williams and Wilkins Company, New York, 1977. 6. Wilder, B.J., Ramsay, R.E., Willmore, L. J.: Hematological effects of phenytoin therapy during pregnancy. Obstetrics and Gynecology 53:682-685, 1978. 7. Willmore, L.J., Wilder, B.J.: "Epilepsy and Other Convulsive Disorders." In: Current Diagnosis Fifth Edition, H.F., Conn and R.N. Conn, Editors W.B. Saunders Company, Philadelphia, Pennsylvania. 1977, pp. 990-993. 8. Ramsay, R.E., Strauss, R., Wilder, B.J., Willmore, L.J.: Status epilepticus in pregnancy: Effect of phenytoin malabsorption on seizure control. Neurology 28:85-89, 1978. 9. Butler, A.B., Willmore, L.J., Fuller, P.M., Bass, N.H.: Cytochemical affinity of pyramidal cell dendrites for divalent cobalt during initiation and calcium-induced blockage of epileptiform discharge. Experimental Neurology 56:386-399, 1977. 10. Willmore, L.J., Ramsay, R.E., Mayersdorf, A., Sypert, G.W., Wilder, B.J.: Assessment of speech lateralization by the intracarotid injection of methohexital. Annals of Neurology 4:86-88, 1978. 11. Strauss, R.G., Ramsay, R.E., Willmore, L.J., Wilder, B.J.: Hematological effects of phenytoin therapy during pregnancy. Obstetrics and Gynecology 53:682-685, 1978. 12. Strauss, R.G., Ramsay, R.E., Wilder, B.J., Willmore, L.J.: Epilepsy and pregnancy: Serum thyroxin level during phenytoin therapy. Obstetrics and Gynecology 53:344-347, 1979. 13. Willmore, L.J., Sypert, G.W., Munson, J.B.: Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex. Science 200:1501-1503, 1978. 14. Willmore, L.J., Sypert, G.W., Munson, J.B.: Recurrent seizures induced by cortical iron injection: A model of post-traumatic epilepsy. Annals of Neurology 4:329-336, 1978. 15. Willmore, L.J., Sypert, G.W.: Epileptiform activity initiated by pial iontophoresis of ferrous and ferric chloride into rat cerebral cortex. Brain Research 152:406-410, 1978. 16. Wilder, B.J., Willmore, L.J., Bruni, J., Villarreal, H.J.: Valproic acid: Interactions with other anticonvulsant drugs. Neurology 28:892-896, 1978. 17. Bruni, J., Willmore, L.J., Wilder, B.J.: Steady state kinetics of valproic acid in epileptic patients. Clinical Pharmacology and Therapeutics 24:324-332, 1978. 18. Willmore, L.J., Wilder, B.J., Bruni, J., Villarreal, H.J.: Effect of valproic acid on hepatic function. Neurology 28:961-964, 1978. 19. Villarreal, H.J., Wilder, B.J., Willmore, L.J., Bauman, A.W., Hammond, E.J., Bruni, J.: Effect of valproic acid on spike and wave discharges in patients with absence seizures. Neurology 28:886-891, 1978. 20. Bruni, J., Wilder, B.J., Willmore, L.J.: Clinical efficacy of valproic acid in relation to plasma levels. Canadian Journal of Neurological Sciences 5:385-387, 1978. 21. Bruni, J., Willmore, L.J., Wilder, B.J.: Treatment of post-anoxic intention myoclonus with valproic acid. Canadian Journal of Neurological Sciences 6:39-42, 1979. 22. Perchalski, R.J., Bruni, J., Wilder, B.J., Willmore, L.J.: Simultaneous determination of the anticonvulsants 3-bromocinnamamide and carbamazepine in plasma by HPLC. Journal of Chromatography 163:187-193, 1979. 23. Bruni, J., Wilder, B.J., Barbour, B., Willmore, L.J.: Valproic acid and plasma phenytoin levels. Neurology 29:904-905, 1979. 24. Bruni, J., Willmore, L.J.: Epilepsy and pregnancy. Canadian Journal of Neurological Sciences 6:345-349, 1979. 25. Reid, S.A., Sypert, G.W., Boggs, W.M., Willmore, L.J.: Histopathology of the ferric-induced chronic epileptic focus in cat: A Golgi study. Experimental Neurology 66:205-219, 1979. 26. Bruni, J., Wilder, B.J., Bauman, A.W., Willmore, L.J.: Clinical efficacy and long term effects of valproic acid therapy on spike and wave discharges. Neurology 30:42-46, 1980. 27. Rubin, J.J., Willmore, L.J.: Prevention of iron-induced epileptiform discharges in rats by treatment with antiperoxidants. Experimental Neurology 67:472-480, 1980. 28. Willmore, L.J., Ballinger, W.E., Boggs, W., Sypert, G.W., Rubin, J.J.: Dendritic alterations in rat isocortex within an iron-induced chronic epileptic focus. Neurosurgery 7:142-146, 1980. 29. Willmore, L.J., Rubin, J.J.: Antiperoxidant pretreatment and iron-induced epileptiform discharge in the rat: EEG and histopathologic study. Neurology 31:63-69, 1981. 30. Willmore, L.J., Dunn, A.J., Rubin, J.J.: Changes in (3H) lysine incorporation into protein in a seizure focus in rat isocotex. Brain Research Bulletin 6:463-466, 1981. 31. Thurman, M.D., Willmore, L.J.: A replicative cremation experiment. North American Archaeologist 2:275-283, 1981. 32. Willmore, L.J.: Role of superoxide radicals and lipid peroxidation in the development of posttraumatic epilepsy. Advances in Epileptology 13:331-334, 1982. 33. Willmore, L.J., Rubin, J.J.: Formation of malonylaldehyde and focal brain edema induced by subpial injection of FeCl2 into rat isocortex. Brain Research 246:113-119, 1982. 34. Satz, P., Yanowitz, J., Willmore, L.J.: "Early brain damage and lateral development." In: Interface in Psychology R. Bell, J. Ellis, R. Green, J. Harvey, Editors. Texas Tech University press. 1982. 35. Willmore, L.J., Hiramatsu, M., Kochi, H., Mori, A.: Formation of superoxide radicals, lipid peroxides and edema after FeCl3 injection into rat isocortex. Brain Research 277:393-396, 1983. 36. Willmore, L.J., Rubin, J.J.: Effects of antiperoxidants on FeCl2-induced lipid peroxidation and focal edema in rat brain. Experimental Neurology 83:62-70, 1984. 37. Willmore, L.J., Triggs, W.J.: Phenytoin and corticosteroids: Effect on seizures and lipid peroxidation in experimental post-traumatic epilepsy. Journal of Neurosurgery 60:467-472, 1984. 38. Willmore, L.J., Rubin, J.J.: The effect of tocopherol and dimethyl sulfoxide on focal edema and lipid peroxidation induced by isocortical injection of ferrous chloride. Brain Research 296:389-392, 1984. 39. Triggs, W.J., Willmore, L.J.: In vivo lipid peroxidation in rat brain following intracortical Fe++ injection. Journal of Neurochemistry 42:976-980, 1984. 40. Willmore, L.J.: "Mechanisms and management of posttraumatic epilepsy." In: Neural Trauma: Treatment, Monitoring, and Rehabilitation Issues M.E. Miner and K.A. Wagner, Editors, Butterworth, 1985, pp 99-106. 41. Willmore, L.J., Triggs, W.J., Gray, J.D.: The role of iron-induced hippocampal peroxidation in acute epileptogenesis. Brain Research 382:422-426, 1986. 42. Willmore, L.J.: "Controversies in the use of anticonvulsants to prevent posttraumatic epilepsy." In: Neurotrauma M.E. Miner, and K.A. Wagner Editors, Butterworth, pp 75-82, 1989. 43. Willmore, L.J.: Posttraumatic epilepsy: Cellular mechanisms and implications for treatment. Epilepsia 31:s67-s73, 1990. 44. Triggs, W.J., Willmore, L.J., Bohan, T.P., Lin, S-N: Valproate induced mitrochondrial encephalopathy with ketosis and carnitine deficiency. Archives of Neurology 47:1131-1133, 1990. 45. Willmore, L.J. : "Posttraumatic Epilepsy." In: T.A. Pedley and B. Meldrum, Editors, Recent Advances in Epilepsy. Churchill-Livingston pp 107-117, 1990. 46. Willmore, L.J., Triggs, W.J.: Iron-induced lipid peroxidation and brain injury responses. International Journal of Developmental Neuroscience 9:175-180, 1991. 47. Willmore, L.J., Triggs, W.J., Pellock, J.M. Valproate toxicity:
Risk screening strategies. Journal of Child Neurology 6:3-6, 1991. 49. Willmore, L.J. : "Clinical Manifestations of Valproate Hepatotoxicity." In: R.H. Levy and J.K. Penry, Editors, Valproate Associated Hepatotoxicity Raven Press pp. 3-8, 1991. 50. Willmore, L.J. : "Risk screening strategies." In: R.H. Levy and J.K. Penry, Editors, Valproate Associated Hepatotoxicity Raven Press. pp 162-165, 1991. 51. Triggs, W.J., Roe, C.R., Rhead, W.J., Hanson, S.K., Lin, S-N., Willmore, L.J. Riboflavin responsive neuropsychiatric manifestations of a defect in mitochondrial beta oxidation presenting in an adult. Journal of Neurology, Neurosurgery, and Psychiatry 55:209-211, 1992. 52. Willmore, L.J.: "Prophylactic use of anticonvulsants". In: Medical Treatment of Epilepsy S.R. ` and H. Kutt, Editors. Marcel Dekker, New York, pp 73-77 1992. 53. Willmore, L.J.: "Prophylactic Use of Anticonvulsant Drugs". In: V. Hachinski, Editor, Challenges in Neurology. F.A. Davis pp. 121-125, 1992. 54. Willmore, L.J.: "Prognosis of Epilepsy". In: R.W. Evans, D.S. Baskin, F.M. Yatsu, Editors. Prognosis in Neurologic Disease Oxford Press pp.483-496, 1992. 55. Willmore, L. J., Wheless, J.W. "Adverse effects of antiepileptic drugs." In: E. Wyllie Editor. The Treatment of Epilepsy: Principles and Practice Lea & Febiger, pp 824-834, 1992. 56. Willmore, L.J.: "Posttraumatic Epilepsy." In: R.W. Evans, Editor. The Neurology of Trauma. Neurologic Clinics, W.B. Saunders, 10:869-878, 1992. 57. Leppik, I.E., Willmore, L.J., Homan, R.W., Fromm, G., Oommen, K.J., Penry, J.K., Sackellares, J.C., Smith, D.B., Lesser, R.P., Wallace, J.D., Trudeau, J.L., Lamoreaux, L.K., Spencer, M. Efficacy and safety of Zonisamide: Results of a multicenter study. Epilepsy Research 14:165-173, 1993. 58. Willmore, L.J. Quality of care and quality of life: Challenges for the age of managed competition and the new medical economic. Proceedings of the Royal Society of Medicine 31:97-99 1993. 59. Willmore, L.J.: "Posttraumatic Seizures." In: O. Devinsky, Editor. Epilepsy I: Diagnosis and Treatment. Neurologic Clinics, W.B. Saunders, 11: 823-834, 1993. 60. Messenheimer, J., Ramsay, R.E., Willmore, L.J., Leroy, R.F., Zielinski, J.J., Mattson, R., Pellock, J.M., Valakas, A.M., Womble, G., Risner, M. Lamotrigine therapy for partial seizures: A multicenter, double-blind, crossover trial. Epilepsia: 35:113-121, 1994. 61. Curtis, V.L., Oelberg, D.G., Willmore, L.J. Infertility secondary to valproate. Journal of Epilepsy 7:259-261, 1994. 62. Triggs, W.J., Willmore, L.J., Yeakley, J.W. Magnetic resonance imaging in puerperal seizures: Postpartum eclampsia or cerebral venous thrombosis. Journal of Epilepsy 7:262-267, 1994. 63. Triggs, W.J., Willmore, L.J. Effect of [dl]-(-tocopherol of on FeCl2-induced lipid peroxidation in rat amygdala. Neuroscience Letters 180:33-36, 1994. 64. Barron, B.J., Lamki, L.M., Wheless, J., Curtis, V., Willmore, J., Ephron, V. Initial experience with ictal injection of stabilized Tc-99m exametazime (HMPAO): Patterns and pitfalls. RadioGraphics: Electronic media-CD-ROM, 1994. 65. Abi-Said, D., Annegers, J.F., Combs-Cantrell, D., Frankowski, R.F., Willmore, L.J. A case control study of the risk factors for eclampsia. American Journal of Epidemiology. 142:437 441, 1995. 66. Baumgartner, J., Clifton, G., Wheless, J., Willmore, L., Curtis, V., Brookshire, B. Corpus Callosotomy. Techniques in Neurosurgery 1:45-51, 1995. 67. Devinsky, O., Leppik, I., Willmore, L.J., Pellock, J.M., Dean, C., Gates, J., Ramsay, R.E. Safety of intravenous valproate. Annals of Neurology 38: 670-674, 1995. 68. Willmore, L.J. Calcium antagonists and epilepsy. Mayo Clinic Proceedings 70: 715, 1995. 69. Willmore, L.J. Post-traumatic epilepsy: Mechanisms and prevention. Psychiatry and Clinical Neurosciences 49:171-173, 1995. 70. Willmore, L.J. The Effect of age on pharmacokinetics of antiepileptic drugs. Epilepsia 36: 14-21, 1995. 71. Willmore, L.J., Dulac, O. "Use of Antiepileptic Drugs in Children and the Elderly. In: Levy, R.H., Mattson, R.H., Meldrum, B.S., Editors Antiepileptic Drugs. Fourth Edition. Raven Press pp 231-242, 1995. 72. Willmore, L.J., Plaa, G.L. "General principles: Toxicology of antiepileptic drugs. In: Levy, R.H., Mattson, R.H., Meldrum, B.S., Editors Antiepileptic Drugs Fourth Edition. Raven Press, pp 51-60, 1995. 73. Willmore, L.J., Shu, V., Wallin, B. Efficacy and safety of add-on divalproex sodium in the treatment of complex partial seizures. Neurology 46:49-53, 1996. 74. Habu, H., Yokoi, I., Kabuto, H., Willmore, L.J., Mori, A. Seizures induced by ( guanidinoglutaric acid, an inhibitor of nitric oxide synthase, are controlled by L-Arginine. Biochemistry and Molecular Biology International 39:87-95, 1996. 75. Plenger, P., Breier, J.I., Wheless, J.W., Ridley, T.D., Papanicolaou, A.C., Brookshire, B., Thomas, A., Curtis, V., Willmore, L. J. Lateralization of memory for music: Evidence from the intracarotid sodium amobarbital procedure. Neuropsychologia 34:1015-1018, 1996. 76. Breier, J.I., Plenger, P.M., Wheless, J.W., Thomas, A.B., Brookshire, B.L., Curtis, V.L., Papanicolaou, A., Willmore, L.J., Clifton, G.L. Memory tests distinguish between patients with focal temporal and extratemporal lobe epilepsy. Epilepsia 37:165-170, 1996. 77. Komatsu, M., Hiramatsu, M., Yokoyama, H., Willmore, L.J. Effect of TJ-960 on free radical changes within an iron-induced focal epileptogenic region measured by in vivo L-band electron spin resonance. Neuroscience Letters 205: 189-192, 1996. 78. Privatera, M., Fincham, R., Penry, J. et al and the Topiramate
Study Group: Willmore, 79. Plenger, P.M., Breier, J.I., Wheless, J.W., Papanicolaou, A.C., Brookshire, B., Thomas, A., Curtis, V., Willmore, L.J. Nonverbal selective reminding test: Efficacy in assessment of adults with temporal lobe epilepsy. Journal of Epilepsy 9:65-69, 1996. 80. Silberstein, S., Willmore, L.J. Divalproex sodium: Migraine treatment and monitoring. Headache 36:239-242, 1996. 81. Willmore, L.J., Habu, H. "Free radicals and posttraumatic epilepsy: Induction and limitation of brain injury responses." In: L. Packer, M. Hiramatsu, T. Yoshikawa Editors: Free radicals in brain physiology and disorders. Academic Press San Diego, pp 173-184, 1996. 82. Hiramatsu, M, Nakajima, M., Komatsu, M., Oikawa, K., Ueda, Y., Nakai, O., Willmore, L.J. "Electron spin resonance-computed tomography: Brain imaging and epilepsy. In: L. Packer, M. Hiramatsu, T. Yoshikawa Editors: Free radicals in brain physiology and disorders. Academic Press San Diego, pp 185-196, 1996. 83. Kabuto, H., Yokoi, I., Habu, H., Willmore, L.J., Mori, A., Ogawa, N. Reduction in nitric oxide synthase activity with development of an epileptogenic focus induced by ferric chloride in the rat brain. Epilepsy Research 25:65-68, 1996. 84. Willmore, L.J. Management of epilepsy in the elderly. Epilepsia 37: s23-s33, 1996. 86. Breier, J.I., Brookshire, B.L., Fletcher, J.M., Plenger, P.M., Wheless, J.W., Thomas, A.B., Papanicolaou, A.C., Willmore, L.J. Identification of side of seizure onset in temporal lobe epilepsy using memory tests in the context of reading deficits. Journal of Clinical and Experimental Neuropsychology. 19: 161-171, 1997. 87. Breier, J.I., Mullani, N.A., Thomas, A.B Wheless, J.W., Plenger, Gould, K.L., Papanicolaou, A., Willmore, L.J. Effects of duration of epilepsy on the uncoupling of metabolism and blood flow in complex partial seizures. Neurology 48:1047-1053, 1997. 88. Willmore, L.J., Pellock, J.M. "Long term monitoring strategies." In: J. Engel, Pedley, T.A. Editors: Epilepsy: A Comprehensive Textbook. pp 1255-1259, 1997. 89. Willmore, L.J. "Prophylactic Treatment." In: J. Engel, Pedley, T.A. Editors: Epilepsy: A Comprehensive Textbook pp 1333-1337, 1997. 90. Willmore, L. J., Ferrendelli, J.A. "Epilepsy" In: Scientific American Medicine. 12:1-21, (Text and CD-ROM) 1997. 91. Penry, JK, Willmore, L.J. (Editors) Patterns for epilepsy care: Worldwide perspectives. Neurology 48: S1-S62, 1997. 92. Willmore, L.J. Care of adults with epilepsy in the United States. Neurology 48:S39 S43,1997. 93. Breier, J.I., Thomas, A.B., Plenger, P.M., Wheless, J.W., Brookshire, B., Papanicolaou, A.C., Willmore, L.J. Asymmetries in the effect of side of seizure onset on recognition memory following intracarotid amobarbital injection. Epilepsia 38:1209-1215, 1997. 94. Willmore, L.J. "Posttraumatic epilepsy" In E. Wyllie, Editor, The Treatment of Epilepsy: Principles and Practice, 2nd edition, pp 629-635, 1997. 95. Willmore, L.J., Messenheimer, J.A. Adult experiences with Lamotrigine. Journal of Child Neurology. 12:16-18, 1997. 96. Sorenson, J.M., Wheless, J.W., Baumgartner, J.E., Thomas, A.B., Brookshire, B.L., Clifton, G. L., Willmore, L.J. Corpus callosotomy for medically intractable seizures. Pediatric Neurosurgery 27:260-267, 1997. 97. Abi-Said, D., Annegers, J.F., Combs-Cantrell, D., Suki, R., Frankowski, R.F., Willmore, L.J. A case-control evaluation of treatment efficacy: The example of magnesium sulfate prophylaxis against eclampsia. Journal of Clinical Epidemiology. 50: 419-423, 1997. 98. Willmore, L.J. Antiepileptic drug therapy in the elderly. Pharmacology and Therapeutics 78:9-16, 1998. 99. Breier, J.I., Fuchs, B.L., Brookshire, B Wheless, J.W., Thomas, A.B., Constantinou, J., Willmore, L.J. Quality of life perceptions in patients with intractable epilepsy or with pseudoseizures. Archives of Neurology 55: 660-665, 1998 100. Ueda, Y., Doi, T., Mitsuyama, Y. Willmore, L.J. The effect of valproate on EAATs and GAT-1 protein levels in the hippocampus of FeCl3-induced limbic epilepsy model. Brain Science and Mental Disorders (In Press) 1998. 101. Willmore, L.J. "Valproic acid." In M. Sperling, Editor. The Medical Management of Epilepsy. Marcell Decker. (In Press) 1998. 102. Schachter, SC, Vasquez, B., Fisher, RS, Laxer, KD, Montouris, GD, Combs-Cantrell, DT, Faught, E., Willmore, LJ, Morris, GL, Ojemann, L., Bennett, D., Messenbrink, P., D'Souza, J, Kramer, L. Oxcarbazepine: a double-blind, placebo-controlled, monotherapy trial for partial seizures. Neurology 52: 732-737, 1999 103. Ueda, Y., Willmore, L.J., Triggs, W.J. Amygdalar injection of FeCl3 causes spontaneous recurrent seizures Experimental Neurology 153: 123-127, 1998. 104. Wheless, J.W., Willmore, L.J., Breier, J.I., Kataki, M., Smith, J., King, D.W., Meador, K.J., Park, Y.D., Loring, D.W., Clifton, G.L., Baumgartner, J., Thomas, A.B., Constantinou, J.E.C., Papanicolaou, A.,. A comparison of magnetoencephalography, MRI, and V-EEG in patients evaluated for epilepsy surgery. Epilepsia 40:931-941, 1999. 105. Papanicolaou, A.C., Simos, P.G., Breier, J.I., Zouridakis, G., Willmore, L.J., Wheless, J.W., Constantinou, J.E.C., Maggio, W.W., Gormley, W.B. Magnetoencephalographic mapping of the language-specific cortex. Journal of Neurosurgery 90:85-93, 1999 106. Willmore, L.J. "Treatment of epilepsy in adults" In W. Loscher (Editor) Valproate. Birkhauser, Ltd. Basel, Switzerland. pp 153-166, 1999. 107. Willmore, L.J. Epilepsy emergencies: the first seizure and status epilepticus. Neurology 51: s34-s38, 1998. 108. Willmore, L.J. Choice and use of newer anticonvulsant drugs in older patients. Drugs and Aging 17:441-452, 2000 109. McLean, M.J., Morrell M.J., Willmore, L.J., Privitera, M.D., Faught, R.E., Holmes, G.L., Magnus-Miller, L., Bernstein, P., Rose-Legatt, A. Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. Epilepsia 40:965-972, 1999. 110. Willmore, LJ. How does trauma cause epilepsy? In: P. Kotagal, H.O. Luders (Editors) The Epilepsies: Etiologies and Prevention. Academic Press. 1998. pp 289-291. 111. Simos, PG, Breier,JI, Maggio, WW, Gormley, WB, Zouridakis, G., Willmore, LJ, Wheless, JW, Constantinou, JEC, Papanicolaou, AC. Atypical temporal lobe language representation: MEG and intraoperative stimulation mapping correlation. Neuroreport 10:139-142, 1999. 112. Breier, J.I., Simos, P.G., Zouridakis, G., Wheless, J.W., Willmore, L.J., Constantinou, JEC ,Papanicolaou, A.C. A magnetoencephalography study of cortical plasticity. Neurocase 5:277 284 1999. 113. Breier, J.I., Simos, P.G., Zouridakis, G., Wheless, J.W., Willmore, L.J., Constantinou, J.E.C., Maggio, W.W., Papanicolaou, A.C. Language dominance determined by magnetic source imaging. Neurology 53:938-945, 1999. 114. Doi, T., Ueda, Y., Tokumaru, J., Mitsuyama, Y., Willmore, L.J. Sequential changes in glutamate transporter mRNA during Fe+++ induced epileptogenesis. Molecular Brain Research 75: 105-112, 2000. 115. Ueda, Y., Willmore, L.J. Hippocampal gamma-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdala. Brain Research Bulletin 52:357-361, 2000. 116. Ueda, Y., Willmore, L. J. Sequential changes in glutamate transporter protein levels during Fe+++-induced epileptogenesis. Epilepsy Research 39: 201-219, 2000. 117. Ueda, Y., Willmore, L.J. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Experimental Brain Research. 133:334-339, 2000. 118. Willmore, L.J., Zonisamide. Royal Society of Medicine. Series 245: 1-7, 2000. 119. Willmore, L.J. Antiepileptic drug therapy in the elderly. Clinical Geriatrics 8:28-46, 2000. 120. Komatsu, M., Hiramatsu, M., Willmore, L.J. Zonisamide reduces the increase in 8-hydroxy 2'-deoxyguanosine levels in the brain formed during iron-induced epileptogenesis in rats. Epilepsia 41:1091-1094, 2000. 121. Ueda, Y., Doi, T., Tokumaru, J., Mitsuyama, U., Willmore, L. J. Kindling phenomena induced by the repeated short-term high potassium stimuli in the ventral hippocampus of rats: On-line monitoring of extracellular glutamate overflow. Experimental Brain Research. 135:199 203, 2000. 122. Morrell M.J., McLean, M.J., Willmore, L.J., Privitera, M.D., Faught, R.E., Holmes, G.L., Magnus, L., Bernstein, P., Rose-Legatt, A. Efficacy of gabapentin as adjunctive therapy in a large, multicenter study. Seizure. 9:241-248, 2000. 123. Vinkatraman, VJ, Wheless, J.W., Willmore, LJ, Motooka, H. Idiopathic cardiac asystole presenting as an intractable adult onset partial seizure disorder. Seizure 10: 359-364, 2001. 124. Willmore, L.J. Clinical pharmacology of new antiepileptic drugs. Neurology 55:s17-s24, 2000 125. Ueda, Y., Doi, T., Tokumaru, J., Yokoyama, H., Nakajima, A., Mitsuyama, U., Ohya Nishiguchi, H., Kamada, H., Willmore, L. J. Collapse of extracellular glutamate regulation during epileptogenesis: Down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. Journal of Neurochemistry 76: 829-900, 2001. 126. Doi, T, Ueda, Y., Tokumaru, J., Mitsuyama, Y., Willmore, L.J. Sequential changes in AMPA and NMDA protein levels during Fe+++-induced epileptogenesis Molecular Brain Research 92:107-114, 2001 127. Willmore, L.J. Lamotrigine. Expert Review of Neurotherapeutics. 1:89-98, 2001 128. Willmore, L.J., Ueda, Y. Molecular Biology and Genetics of of Epilepsy. Acta Medica Okayama. 2001 (In Press) 129. Willmore, L.J., Ueda, Y. Genetics of Epilepsy. Journal of
Child Neurology (Suppl) 2001. (In Press) Willmore, L.J. Advances in antiepileptic drugs. Expert Opinion on Investigational Drugs. 2001 Willmore, L.J., Ueda, Y. Molecular Neuropharmacology. Oxford Press. 2001 Willmore, L.J., Ueda, Y. Molecular Biology of Epilepsy. Acta Medica Okayama. 2001 Willmore, L.J. Genetics of Epilepsy. Journal of Child Neurology
(Suppl) 2001. 1. Wilder, B.J., Willmore, L.J., Villarreal, H.J., Bruni, J.: Valproic acid: Clinical, EEG and pharmacological studies in patients with absence seizures. Monograph for the American Academy of Neurology Meeting, April 1978. 2. Willmore, L.J.: "Behavioral Disorders in Epilepsy." Proceedings of Region IV Symposium: Problems in Epilepsy. Medical University of South Carolina Press, Charleston, South Carolina, 1977. 3. Willmore, L.J.: Behavioral Consequences of Epilepsy. In: Epilepsy Monograph, American Academy of Neurology, April 1980. 4. Willmore, L.J.: New Developments in Epilepsy Research: Biochemistry. Epilepsy Monograph, American Academy of Neurology, April 1980. 5. Willmore, L.J.: Book Review, Textbook of Adverse Drug Reactions. Epilepsia. 23:721-722, 1982. 6. Willmore, L.J.: Book Review, The Neurobiology of Zinc. Epilepsia. 26:376, 1985. 7. Willmore, L.J.: "Management of Intractable Epilepsy". In: Clinical Strategies for Patient Care. J. Pellock, Editor. Windermere, 1987 pp 22-29. 8. Willmore, L.J.: "Prophylactic Use of Antiepileptic Drugs". In: Controversies in Epilepsy. American Academy of Neurology, April 1988. 9. Willmore, L.J.: "Behavioral Complications of Epilepsy". In: Borderlands of Neurology. American Academy of Neurology, April 1988. 10. Willmore, L.J.: "Prevention of Posttraumatic Epileptogenesis" In: Epilepsy. American Academy of Neurology May 1990. 11. Willmore, L.J.: "Prognosis of Epilepsy" In: Prognosis of Neurologic Disorders. American Academy of Neurology, May 1993. 12. Willmore, L.J.: "Epilepsy: New Treatment Modalities and Prognosis" In: Prognosis of Neurologic Disorders. American Academy of Neurology, May 1994. 13. Willmore, L.J.: "Pharmacokinetics of the Antiepileptic Drugs" In: Clinical Epilepsy American Academy of Neurology, May 1994. 14. Willmore, L.J.: "Posttraumatic Epilepsy" Epilepsy Quarterly 2:1-5. 1994. 15. Willmore, L.J.: "Post-traumatic epilepsy: Mechanisms and prevention." Neuroscience Research Center Newsletter. 2 (2) 1-5, 1995. 16. Willmore, L.J. Book Review: "Epilepsy: 100 elementary Principles, 3rd ed" Neurology 46: 895, 1996. 17. Penry, JK, Willmore, L.J. (Editors) Patterns for epilepsy care: Worldwide perspectives. Neurology 48 (Suppl 8),1997. 18. Willmore, LJ. (Editor) Interpretation of new technology and clinical care challenges. Epilepsia 38 (Suppl 4), 1997 19. Willmore, LJ. (Editor) Extra-temporal seizures: diagnosis and management. Epilepsia 39 (Suppl 4) 1998. 20. Yamauchi, T., Willmore, LJ. Posttraumatic Epilepsy. In Worldwide Topics in Epilepsy. (Japanese) Interview series: Issue 6. Adis International, Osaka, Japan. 21. Beydoun, A., Willmore, LJ. Monotherapy for epilepsy: Choice and use of established drugs. Abcomm, Inc. 1998. Chicago, Ill. 22. Willmore, LJ. (Editor) Epilepsy in the elderly: Current concepts in understanding and treatment. American Epilepsy Society. 1998. Hartford, CN. 23. Willmore L. J. Saint Louis University School of Medicine.
St. Louis Metropolitan Medicine 21:18-19, 1999. 2. Willmore, L.J.: Valproic Acid in Treatment of Postanoxic Myoclonus. Archives of. Neurology. 40:325-1983. 3. Willmore, L.J.: Role of iron in free radical formation and brain edema. Neurology. 34:1525, 1984. 4. Shu, V.S., Willmore, L.J. "Intent-to-treat" Neurology 47:1357-1357, 1996, 5. Schachter, SC, Vasquez, B., Fisher, RS, Laxer, KD, , Combs-Cantrell,
DT, Faught, E., Willmore, LJ, Morris, GL, Ojemann, L. Montouris, GD. Oxcarbazepine
monotherapy trial for partial seizures-Placebo-controlled studies in neurology:
Where do they stop? Neurology. 53: 2211-2213, 1999 Willmore, L.J. "Medical school? Start planning now." The Atlanta Journal and Constitution. Editor-Elliott Brack for "What's Next?" 5: (no.3) page 2, August 1999. Willmore, L.J. "Becoming a doctor: Secrets they never tell you." The Atlanta Journal and Constitution. Editor-Elliott Brack for "What's Next?" 5: (no. 4) page 21, September 1999. Willmore, L.J. "The medical school interview." The Atlanta Journal and Constitution. Editor Elliott Brack for "What's Next?" 5: (no. 6) page 23, November 1999. Willmore, L.J. "Avoid roadblocks by evaluating advice" The Atlanta
Journal and Constitution. Editor-Elliott Brack for "What's Next?" 6: (no. 4)
page 23, May 16, 2000. November 1996 |
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